Nutrition medicine = food and/or supplements as medicine
resveratrol -vs- type-2 diabetes
“The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression……in subjects with Type 2 diabetes mellitus.”
“…studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1 activity. Sub- sequent upregulation of AMPK and GLUT4 expression are associated with improved insulin sensitivity in peripheral tissues.”
“10 subjects….randomized in a double-blind….”
“3g resveratrol or placebo daily for 12 weeks”
“There was a significant increase in both SIRT1 expression and p-AMPK to AMPK expression ratio in the resveratrol group compared with the placebo group.”
“In patients with type-2 diabetes, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. These findings indicate that resveratrol may have beneficial exercise-mimetic effects in patients with type-2 diabetes.”
K.P. Goh, et al
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
International Journal of Sport Nutrition and Exercise Metabolism — Volume 24 #1, February 2014 — page 2