antibiotics and brain dysfunction……
“Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health.”
“16S rDNA sequencing confirmed antibiotic-induced microbial community disruption, and metabolomics revealed that gut dysbiosis was associated with depletion of bacteria-derived metabolites in the colon and alterations of lipid species and converted microbe-derived molecules in the plasma.”
.
“Importantly, novel object recognition, but not spatial, memory was impaired in antibiotic-treated mice.”
.
” This cognitive deficit was associated with brain region-specific changes in the expression of cognition-relevant signaling molecules, notably brain-derived neurotrophic factor, N-methyl-d-aspartate receptor subunit 2B, serotonin transporter and neuropeptide Y system.”
.
“We conclude that circulating metabolites and the cerebral neuropeptide Y system play an important role in the cognitive impairment and dysregulation of cerebral signaling molecules due to antibiotic-induced gut dysbiosis.”
.
E.E. Fröhlich, et al
Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
Brain, Behavior, and Immunity — Volume 56 — August 2016 — page 140