“Interactions between the digestive system and the brain functions have
become in recent years an important field of psychiatric research. These
multidirectional interactions take place in the so called
microbiota-gut-brain axis and emerging scientific data indicate to the
significant role of microbiota in the modulation of the central nervous
system including affective and cognitive functions.”
“An assessment of psychobiotic and immunomodulatory effects of probiotic bacteria
Lactobacillus Plantarum 299v by measuring affective, cognitive
functions and biochemical parameters in patients with major depressive
disorder undergoing treatment with selective serotonin reuptake
inhibitors (SSRI).”
.
“79 patients with major depressive
disorder were randomized and allocated to a double-blind,
placebo-controlled trial. Participants received either a selective
serotonin reuptake inhibitors with the probiotic LP299v (n = 40) for a
period of 8 weeks or a selective serotonin reuptake inhibitors with the
placebo of the probiotic (n = 39) for the same period.”
.
“60
participants finished the study and were analyzed: 30 participants in
the LP299v group and 30 participants in the placebo group.”
.
“Augmentation of selective serotonin reuptake inhibitors treatment with
probiotic bacteria Lactobacillus Plantarum 299v improved cognitive
performance and decreased KYN concentration in major depressive disorder
patients. Decreased KYN concentration could contribute to the
improvement of cognitive functions in the LP299v group compared to the
placebo group.”
.
“To our knowledge results of this study are
the first evidence of improvement of cognitive functions in major
depressive disorder patients due to probiotic bacteria and this is the
first evidence of decreased KYN concentration in major depressive
disorder patients due to probiotic bacteria.”
.
L.Rudzki, et al
Probiotic Lactobacillus Plantarum 299v decreases kynurenine
concentration and improves cognitive functions in patients with major
depression: A double-blind, randomized, placebo controlled study
Psychoneuroendocrinology — Volume 100 — February 2019 — page 213