“Interactions between the digestive system and the brain functions have become in recent years an important field of psychiatric research. These multidirectional interactions take place in the so called microbiota-gut-brain axis and emerging scientific data indicate to the significant role of microbiota in the modulation of the central nervous system including affective and cognitive functions.”
“An assessment of psychobiotic and immunomodulatory effects of probiotic bacteria Lactobacillus Plantarum 299v by measuring affective, cognitive functions and biochemical parameters in patients with major depressive disorder undergoing treatment with selective serotonin reuptake inhibitors (SSRI).”
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“79 patients with major depressive disorder were randomized and allocated to a double-blind, placebo-controlled trial. Participants received either a selective serotonin reuptake inhibitors with the probiotic LP299v (n = 40) for a period of 8 weeks or a selective serotonin reuptake inhibitors with the placebo of the probiotic (n = 39) for the same period.”
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“60 participants finished the study and were analyzed: 30 participants in the LP299v group and 30 participants in the placebo group.”
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“Augmentation of selective serotonin reuptake inhibitors treatment with probiotic bacteria Lactobacillus Plantarum 299v improved cognitive performance and decreased KYN concentration in major depressive disorder patients. Decreased KYN concentration could contribute to the improvement of cognitive functions in the LP299v group compared to the placebo group.”
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“To our knowledge results of this study are the first evidence of improvement of cognitive functions in major depressive disorder patients due to probiotic bacteria and this is the first evidence of decreased KYN concentration in major depressive disorder patients due to probiotic bacteria.”
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L.Rudzki, et al
Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
Psychoneuroendocrinology — Volume 100 — February 2019 — page 213