“Mitochondrial bioenergetics is critical for immune function in natural killer cell. Physical exercise modulates natural killer cell functionality, depending on the intensity and type of exercise.”

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“This study elucidates how interval and continuous exercise regimens affect the phenotypes and mitochondrial bioenergetics of natural killer cells.”

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“60 healthy sedentary males were randomly assigned to engage in either high-intensity interval training (HIIT, 3-min intervals at 80% and 40% maximal O 2 , or moderate-intensity continuous training (MICT, sustained 60% maximal O 2, for 30 min·per day −1 , 5 days per week −1 for 6 weeks) or were assigned to a control group that did not receive exercise intervention.”

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“Either HIIT or MICT increases the expressions of cytotoxic granule proteins and depresses mitochondrial MOB elevated by GXT, along with improving mitochondrial bioenergetic functionality in natural killer cells. Moreover, HIIT is superior to MICT in improving aerobic capacity.”

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Lin, Ming-lu, et al

Exercise Training Improves Mitochondrial Bioenergetics of Natural Killer Cells

Medicine & Science In Sports & Exercise — Volume 54 #5 — May 2022 — page 751