TheElite Training Group track club [theetg@theetgtrackclub.com]

Expanding the area of what is possible

In Track & Field Distance Running & Competent Self-Care in medicine and psychology

 

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As you continue to acquire and apply more information you continue to expand the area of what is possible.

“I don’t know that there is any magic level of interest in science that people ought to have. But the more they understand, the more they will be able to control their destiny and achieve their other aims.” —[Stephen Hawking]

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Data-less conclusions founded upon faulty assumptions are the mother of all screw-ups.

They lead to human belief systems that quickly get set in stone insuring that new information gets shouted down as group think, ego, and resistance to change supplant data, logic and reason. In all areas of applied science and particularly in anything having to do with human performance, age & aging, and “its genetic”…..avoid group think, pursue critical thinking, engage in intellectual honesty.

Put data ahead of dogma. Follow the data -not- the crowd.

“In God we trust…Everyone else must bring data.” —[W.Edwards Deming]

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The functioning of brain cells, muscle cells, blood cells, -all cells- are governed by the laws of nature, -not- your chosen belief system.

The laws of nature -are- the underlying mechanisms of how everything works. Science identifies and describes the laws of nature. Problems often occur with the interpretation and application of science, rather than with science itself.  The all too typical…”science doesn’t explain everything” argument cannot be inserted each time one’s comfort zone is challenged. The all too typical…”its genetic” argument cannot be inserted each time one cannot explain something. The laws of nature that control human cellular function are -not- governed by your chosen belief system or the dogma you have been indoctrinated into, or the dogma you refuse to set aside.

“Nature, to be commanded, must be obeyed.” —[Francis Bacon]

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Critical Thinking is the opposite of blind engagement in group think. It is applied Intellectual Honesty.

In track & field distance running, in medicine, in psychology, and in parenting, critical thinking should consist of at least 2 main required actions.

[1] Always think and reason in terms of underlying mechanisms of how things work.

[2] Respond to any assumption, especially your own, with the question….why is that. Be willing to give and embrace an intellectually honest answer.

“Refrain from illusions, insist on work and not words, patiently seek divine and scientific truth.”—[Maria Mendeleeva]

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To be a good track coach one must -first- be a good physiologist.

To be a good medical doctor one must -first- be a good physiologist..

To be a good physiologist one must -first- be willing to…………

— put data ahead of dogma, follow the data -not- the crowd

— put science ahead of indoctrinated tradition

— put logic and reason ahead of faulty assumptions

— put mechanisms ahead of correlations and “risk factors”

— put critical thinking and clinical reasoning ahead of a memorized set of “if–then” statements

— read and apply large amounts of published research

— accept outcomes as the judge and jury of your work

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TheETG Track & Field Promotions Project —– http://theetgtrackclub.com/documents/TheETGTrackPromotionmasterofsport.pdf

TheETG “This Is Track & Field” document —– http://theetgtrackclub.com/documents/TheETGThisIsTrack&Fieldmasterofsport.pdf

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2019 professional Track & Field TV schedule

—– January — time/channel coming — Armory Track Invitational [New York]

—– February — time/channel coming — Milrose Games [New York]

—– February — time/channel coming — New Balance Indoor Grand Prix [Boston, Massachusetts]

—– February — time/channel coming — Indoor USA Track & Field Championships

—– April — time/channel coming — Texas Relays [Austin Texas]

—– May  – time/channel coming – Diamond League [Doha, Qatar]

—– May – time/channel coming – Diamond League [Shanghai, China]

—– May – time/channel coming – Boston Games [Boston, Massachusetts]

—– May – time/channel coming – Prefontaine Classic [Eugene, Oregon]

—– May – time/channel coming – Diamond League [Rome, Italy]

—– June – time/channel coming – Diamond League [Oslo, Norway]

—– June – time/channel coming – Diamond League [Stockholm, Sweden]

—– June – time/channel coming – USA Track & Field Championships

—– June – time/channel coming – Diamond League [Paris, France]

—– July – time/channel coming – Diamond League [Lausanne, Switzerland]

—– July – time/channel coming – Diamond League [Rabat, Morocco]

—– July – time/channel coming – Diamond League [Monaco]

—– July – time/channel coming – Diamond League [London, United Kingdom]

—– August — time/channel coming — World Track & Field Championships [Doha, Qatar]

—– August — time/channel coming — Diamond League [Birmingham, United Kingdom]

—– August — time/channel coming — Diamond League [Zurich, Switzerland]

—– August — time/channel coming — Diamond League [Brussels, Belgium]

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—– 2021 — [time/channel coming] — World Track & Field Championships [Eugene, Oregon]

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The ETG Competent Self-Care Project

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A major part of TheETG mission is to expand the area of what is possible in competent self-care in medicine and psychology. TheETG’s primary method of achieving that is to proliferate applied science based information by way of –free– packets containing plain language info for “the average joe” seeking to move themselves or others forward in these areas.

These packets attempt to address the following problem………….

 

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Competent Self-Care: Medicine…….The best medicine comes with no risk-versus-benefit equations to contemplate, no daily violations of “first, do no harm”, no whac-a-mole medicine being practiced to medicate each health issue as it pops up. To be a good doctor one must -first- be a good physiologist. And in order to have a fully functioning health care system available to all human beings in America its core must be comprised of competent self-care and good physiologists.

Competent Self-Care: Psychology…….So-called “mental health professionals” should practice more mental health and less pharmacology. The goal of applied psychology is to empower people to achieve self-mastery. This should be the goal of competent self-care and all psychologists. Parenting….dysfunction moves from the parents, into the home, into the kids, into the streets, into the norm. Personal growth toward being a fully functional human being can move from the parents, into the home, into the kids, into the streets, into the norm.

see the free pdf packets on “Competent Self-Care Packets” page of this website.

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To be a good medical patient one must -first- be a good consumer.

To be a good consumer of health care services one must be willing to….

put fixing a problem ahead of medicating one

discern between what is known and what -your- doctor knows

put outcomes ahead of loyalty to your doctor and your doctor’s kind demeanor

put your life ahead of loyalty to your doctor

avoid emtionalizing disease and allowing emotion to make health care choices

avoid seeking a 2nd opinion from practitioners of the same brand name of medicine that produced the first one

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TheETG Medical Message Of The Day

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“…..to determine the impact of all-cause inpatient harms on hospital finances and patient clinical outcomes.”
“A retrospective analysis of inpatient harm from 24 hospitals in a large multistate health system was conducted during 2009 to 2012….”
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“Inpatient harms were detected and categorized into harm (F–I), temporary harm (E), and no harm.”
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“Of the 21,007…..2818 (13.4%) experienced temporary harm, and 2579 (12.3%) experienced harm.”
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“A patient with harm was estimated to have higher total cost ($4617), higher variable cost ($1774), lower contribution margin (−$1112), longer length of stay (2.6 days), higher mortality probability (59%), and higher 30-day readmission probability (74.4%).”
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“A patient with temporary harm was estimated to have higher total cost ($2187), higher variable cost ($800), lower contribution margin (−$669), longer length of stay (1.3 days), mortality probability not statistically different, and higher 30-day readmission probability (54.6%).”
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“Total health system reduction of harm was associated with a decrease of $108 million in total cost, $48 million in variable cost, an increase of contribution margin by $18 million, and savings of 60,000 inpatient care days.”
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“This all-cause harm safety study indicates that inpatient harm has negative financial outcomes for hospitals and negative clinical outcomes for patients.”
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L.Alder, et al
Impact of Inpatient Harms on Hospital Finances and Patient Clinical Outcomes
Journal of Patient Safety — Volume 14 #2 — June 2018 — page 67
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“……the benefits that US health care currently deliver may not outweigh the aggregate health harm it imparts.”
Journal Of The American Medical Association…Volume 302 #1..July 1, 2009…page 89 – 91

“…..to determine the impact of all-cause inpatient harms on hospital finances and patient clinical outcomes.”
“A retrospective analysis of inpatient harm from 24 hospitals in a large multistate health system was conducted during 2009 to 2012….”
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“Inpatient harms were detected and categorized into harm (F–I), temporary harm (E), and no harm.”
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“Of the 21,007…..2818 (13.4%) experienced temporary harm, and 2579 (12.3%) experienced harm.”
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“A patient with harm was estimated to have higher total cost ($4617), higher variable cost ($1774), lower contribution margin (−$1112), longer length of stay (2.6 days), higher mortality probability (59%), and higher 30-day readmission probability (74.4%).”
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“A patient with temporary harm was estimated to have higher total cost ($2187), higher variable cost ($800), lower contribution margin (−$669), longer length of stay (1.3 days), mortality probability not statistically different, and higher 30-day readmission probability (54.6%).”
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“Total health system reduction of harm was associated with a decrease of $108 million in total cost, $48 million in variable cost, an increase of contribution margin by $18 million, and savings of 60,000 inpatient care days.”
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“This all-cause harm safety study indicates that inpatient harm has negative financial outcomes for hospitals and negative clinical outcomes for patients.”
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L.Alder, et al
Impact of Inpatient Harms on Hospital Finances and Patient Clinical Outcomes
Journal of Patient Safety — Volume 14 #2 — June 2018 — page 67
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“……the benefits that US health care currently deliver may not outweigh the aggregate health harm it imparts.”
Journal Of The American Medical Association…Volume 302 #1..July 1, 2009…page 89 – 91

“In April, the WHO declared that the problem “threatens the achievements of modern medicine. A post-antibiotic era — in which common infections and minor injuries can kill — is a very real possibility for the 21st century.”
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“……a report on antibiotic resistance linked to an executive order from President Barack Obama, who directed the National Security Council to work with a governmental task force and a nongovernmental advisory council to develop a national action plan by February 2015.”
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“…..antibiotics in a market that is currently worth more than $40 billion annually for drugs that are starting to fail.
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C.Nathan, M.D., et al
Resistance — Problems, Progress, and Prospects
New England Journal Of Medicine…..volume 371 #19…..November 6, 2014….page 1761 – 1763
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[CNBC, December 11, 2014…..Drug resistance deadlier than cancer by 2050……by Catherine Boyle]
“Infections resistant to medicines will kill more people per year than cancer by 2050, and cost the world $100 trillion annually, according to a U.K. government-backed report led by Jim O’Neill, the well-known former Goldman Sachs economist.”
“The wide-ranging study, called the Review on Antimicrobial Resistance, was commissioned by the U.K. government earlier this year amid growing concerns about drug-resistant “superbugs”, including new strains of E. coli, malaria and tuberculosis.”.
“Its forecasts, based on research by RAND Europe and KPMG, suggest that drug resistance, which is estimated to have caused around 700,000 deaths globally this year, will cause 10 million by 2050 if further action is not taken.”
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“In the study, 18% of physicians or other providers rejected the recommendations and continued giving their patients the antibiotics they had prescribed. Patients whose health care professionals didn’t follow those recommendations had a 3.5% readmission rate within 30 days and an 82-hour average length of stay. But when physicians and other providers did follow the guidance to stop or change an antimicrobial, their patients had no readmissions and a 68-hour average length of stay.”
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“Inappropriate antibiotic use most likely occurred in patients receiving ceftriaxone/cefotaxime (62%), vancomycin (11%), and meropenem (5%). The most common diagnoses that triggered a recommendation to change antibiotic use were pneumonia (22%), urinary tract infection (19%), and presumed sepsis (9%).”
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A.Slomski
Antibiotics for Children: When Less Is More
Journal Of The American Medical Association…..Volume 312 #20…..November 26, 2014……page 2079 – 2080

 

 

[FDA, December 24, 2013]
“……antibacterial soap products contain chemical ingredients, such as triclosan and triclocarban, which may carry unnecessary risks given that their benefits are unproven.”
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“New data suggest that the risks associated with long-term, daily use of antibacterial soaps may outweigh the benefits,” Rogers says. There are indications that certain ingredients in these soaps may contribute to bacterial resistance to antibiotics, and may have unanticipated hormonal effects that are of concern to FDA.”
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[FDA, September 2, 2016]
“Companies will no longer be able to market antibacterial washes with these ingredients because manufacturers did not demonstrate that the ingredients are both safe for long-term daily use and more effective than plain soap and water in preventing illness and the spread of certain infections.

“This final rule applies to consumer antiseptic wash products containing one or more of 19 specific active ingredients, including the most commonly used ingredients – triclosan and triclocarban.”

“Consumers may think antibacterial washes are more effective at preventing the spread of germs, but we have no scientific evidence that they are any better than plain soap and water,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research. “In fact, some data suggests that antibacterial ingredients may do more harm than good over the long-term.”

 

 

 

 

“Begin with the end in mind”—-[Stephen Covey]
Photo of the stuff that I put my food/drink in or on. Along the path to better nutrient consumption, weight loss, and/or better supplements, etc in today’s world it may be wise to look at what you place your food in or on. Glass may reduce your consumption of stuff over the long term that may leach into your food or drink. Plastic particles, plasticizer chemicals, paints, dies, etc. that over a period of years or decades can gradually endup inside your body, and subsequently inside your cells.
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In our country at present, portion size is the low hanging fruit in the subject matter of weight loss. Perform this task…..visit an antique shop. Look at the standard plate size in the1920’s – 50’s. Compare them to what you have in your kitchen cabinets today. The first thing that goes through people’s minds when they go to smaller plates is….”how do I fit all my food on such a small plate”. That’s pretty much the point. You don’t fit [and can’t] fit all the volume of food you’re accustomed to eating on the small plate.

 

 

 

 

“Endothelial progenitor cells and microparticles are emerging as novel markers of cardiovascular disease risk, which could potentially be modified by dietary fat. We have previously shown that replacing dietary saturated fatty acids with monounsaturated or n–6 (ω-6) polyunsaturated fatty acids improved lipid biomarkers, blood pressure, and markers of endothelial activation, but their effects on circulating endothelial progenitor cells and microparticles are unclear.”
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“The Dietary Intervention and VAScular function Study investigated the replacement of 9.5–9.6% of total energy contributed by saturated fatty acids with monounsaturated fatty acids or n–6 polyunsaturated fatty acids for 16 weeks on endothelial progenitor cells and microparticle numbers in United Kingdom adults with moderate cardiovascular disease risk.”
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“In this randomized, controlled, single-blind, parallel-group dietary intervention, men and women aged 21–60 years (n = 190) with moderate cardiovascular disease risk consumed 1 of three 16-weeks isoenergetic diets.”
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“The monounsaturated fatty acids-rich diet increased endothelial progenitor cell numbers (+28.4%).”
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“Replacement of….. saturated fatty acids with monounsaturated fatty acids increased endothelial progenitor cells numbers, and replacement with either saturated fatty acids with monounsaturated or n–6 polyunsaturated fatty acids decreased microparticle numbers, suggesting beneficial effects on endothelial repair and maintenance.”
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M.Weech, et al
Replacement of dietary saturated fat with unsaturated fats increases numbers of circulating endothelial progenitor cells and decreases numbers of microparticles: findings from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study
American Journal Of Clinical Nutrition — Volume 107 #6 — June 2018 — page 876
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TheETG nutrition medicine —–
http://theetgtrackclub.com/documents/TheETGnutrimedicine.pdf
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TheETG heart disease repair —–
http://theetgtrackclub.com/documents/TheETGheartfix.pdf

 

 

“Walking pace is associated with risk of premature mortality.”
“We examined the associations between walking pace and cause-specific mortality, investigating the potential modifying effect of factors such as total physical activity volume, highest physical activity intensity, age, sex and body mass index.”
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“Prospective pooled analysis of 11 population-based baseline surveys in England and Scotland between 1994 and 2008 that were linked with mortality records.”
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“50,225 walkers were entered in the core analyses. Among participants who did not experience an event in the first 2 years of follow-up (n=49 731), walking at an average or brisk/fast pace was associated with a reduced risk of all-cause (20%) and 24%, respectively) and Cardiovascular disease mortality (24% and 21%, respectively), compared with reporting walking at a slow pace.”
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“……such associations were evident among those over 50 years, those not meeting the physical activity recommendations and those who did not undertake vigorous-intensity activity.”
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“No associations were seen between pace and cancer mortality.”
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“…..these analyses suggest that increasing walking pace could reduce risk for all-cause and Cardiovascular Disease mortality. Walking pace could be emphasised in public health messages, especially in situations when increase in walking volume or frequency is less feasible.”
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E.Stamatakis, et al
Self-rated walking pace and all-cause, cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts
British Journal Of Sports Medicine — Volume 52 #12 — June 2018
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Training To Live Training For Life………

TheETG exercise program —–
http://theetgtrackclub.com/documents/TheETGexerciseprogram.pdf
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TheETG heart disease repair —–
http://theetgtrackclub.com/documents/TheETGheartfix.pdf
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TheETG type 2 diabetes repair —–
http://theetgtrackclub.com/documents/TheETGtypetwodiabetes.pdf
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TheETG mechanisms of aging —–
http://theetgtrackclub.com/documents/TheETGmechanismsaging.pdf
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TheETG cancer repair —–
http://theetgtrackclub.com/documents/TheETGcancerkill.pdf
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http://theetgtrackclub.com/selfcare

 

 

The quackery of tradional medicine……….
“Statins are the most widely prescribed, cholesterol-lowering drugs in the world.”
“Despite the expiration of their patents, revenue for statins is expected to rise, with total sales on track to reach an estimated $1 trillion by 2020.”
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“A bitter dispute has erupted among doctors over suggestions that statins should be prescribed to millions of healthy people at low risk of heart disease. There are concerns that the benefits have been exaggerated and the risks have been underplayed.”
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“….the raw data on the efficacy and safety of statins are being kept secret and have not been subjected to scrutiny by other scientists.”
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“Doctors and patients are being misled about the true benefits and harms of statins……”
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M.Demasi
Statin wars: have we been misled about the evidence? A narrative review
British Journal Of Sports Medicine — Volume 52 #14 — July 2018

good bacteria & immune system functioning………
“A mounting body of evidence indicates that diverse microbial metabolites profoundly regulate the immune system via host receptors and other target molecules.”
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“Immune cells express metabolite‐specific receptors such as P2X7, GPR41, GPR43, GPR109A, aryl hydrocarbon receptor precursor (AhR), pregnane X receptor (PXR), farnesoid X receptor (FXR), TGR5 and other molecular targets.”
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“Microbial metabolites and their receptors form an extensive array of signals to respond to changes in nutrition, health and immunological status. As a consequence, microbial metabolite signals contribute to nutrient harvest from diet, and regulate host metabolism and the immune system.”
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“Importantly, microbial metabolites bidirectionally function to promote both tolerance and immunity to effectively fight infection without developing inflammatory diseases. In pathogenic conditions, adverse effects of microbial metabolites have been observed as well. Key immune‐regulatory functions of the metabolites, generated from carbohydrates, proteins and bile acids, are reviewed in this article.”
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CH.Kim
Immune regulation by microbiome metabolites
Immunology — Volume 154 #2 — June 2018 — page 220

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good bacteria -vs- multiple sclerosis…………
“A vast number of studies have demonstrated a remarkable role for the gut microbiota and their metabolites in the pathogenesis of inflammatory diseases, including multiple sclerosis.”
“Recent studies in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, have revealed that modifying certain intestinal bacterial populations may influence immune cell priming in the periphery, resulting in dysregulation of immune responses and neuroinflammatory processes in the central nervous system.”
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“Conversely, some commensal bacteria and their antigenic products can protect against inflammation within the central nervous system.”
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“Specific components of the gut microbiome have been implicated in the production of pro‐inflammatory cytokines and subsequent generation of Th17 cells. Similarly, commensal bacteria and their metabolites can also promote the generation of regulatory T‐cells, contributing to immune suppression.”
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“Short‐chain fatty acids may induce Treg either by G‐protein‐coupled receptors or inhibition of histone deacetylases. Tryptophan metabolites may suppress inflammatory responses by acting on the aryl hydrocarbon receptor in T‐cells or astrocytes.”
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“Interestingly, secretion of these metabolites can be impaired by excess consumption of dietary components, such as long‐chain fatty acids or salt, indicating that the diet represents an environmental factor affecting the complex crosstalk between the gut microbiota and the immune system.”
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“This review discusses new aspects of host–microbiota interaction and the immune system with a special focus on multiple sclerosis as a prototype T‐cell‐mediated autoimmune disease of the central nervous system.”
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S.H.Aiden, et al
Impacts of microbiome metabolites on immune regulation and autoimmunity
Immunology — Volume 154 #2 — June 2018 — page 230

 

 

“A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach.”
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L.G.Radvanyi
Targeting the cancer mutanome of breast cancer
Nature Medicine — Volume 27 #6 — June 2018 — page 703

 

Amazing, all new, 21rst Century medical breakthroughs
Breaking news, this just in……
— An upset stomach isn’t caused by a Tums or Rolaids deficiency
— Depression isn’t caused by an anti-depressant deficiency
— Heart Disease isn’t caused by a cholesterol lowering drug deficiency
— Cancer isn’t caused by a chemotherapy or radiation deficiency
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Our changing health care system.
Here are –your– new doctors. There are many.
Several are specialists. Meet with them regularly.
They will help you add decades of youthful living to your life.
Here are their names…..
Dr. Walking
Dr. Sleep
Dr. Sunset-watching
Dr. Down-Time
Dr. Nutrition
Dr. Laughter-StandupComedy
Dr. Strength training
Dr. Relaxation
Dr. Sunlight-Exposure
Dr. Yoga
Dr. Meditation
Dr. Jogging
Dr. Nutrient-Based-Medicine
Dr. Mind-Body Medicine

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“Better health care will depend, not on some new therapeutic standard, but on the level of willingness and competence to engage in self care.”
[Dr. I. Illich….1978]

“Increasing concern is evident about contamination of foodstuffs…..”
“Common off-the-shelf varieties of black, green, white, and oolong teas sold in tea bags were used for analysis in this study. Toxic element testing was performed on 30 different teas…..”
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“All brewed teas contained lead with 73% of teas brewed for 3 minutes and 83% brewed for 15 minutes having lead levels considered unsafe for consumption during pregnancy and lactation. Aluminum levels were above recommended guidelines in 20% of brewed teas.”
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“No mercury was found at detectable levels in any brewed tea samples.”
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“….manganese levels were found to be excessive in some black teas.”
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Toxic contamination by heavy metals was found in most of the teas sampled. Some tea samples are considered unsafe.”
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“There are no existing guidelines for routine testing or reporting of toxicant levels in “naturally” occurring products. Public health warnings or industry regulation might be indicated to protect consumer safety.”
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G.Schwalfenberg, S.J. Genuis, I.Rodushkin
The Benefits and Risks of Consuming Brewed Tea: Beware of Toxic Element Contamination
Journal Of Toxicology — October 23, 2013

Game changer!
Potential to permantly alter the drug company industry. Box of baking soda costs less than $1. Inflamation and auto-immune diseases are a massive chunk of drug company profits.

[results of a 1/2 teaspoon of baking soda in bottle of water for 2 weeks]……

“In the spleen, as well as the blood and kidneys, they found after drinking water with baking soda for two weeks, the population of immune cells called macrophages, shifted from primarily those that promote inflammation, called M1, to those that reduce it, called M2. Macrophages, perhaps best known for their ability to consume garbage in the body like debris from injured or dead cells, are early arrivers to a call for an immune response.”
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“Clinical trials have shown that a daily dose of baking soda can not only reduce acidity but actually slow progression of the kidney disease, and it’s now a therapy offered to patients.”
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“The scientists also saw a shift in other immune cell types, like more regulatory T cells, which generally drive down the immune response and help keep the immune system from attacking our own tissues. That anti-inflammatory shift was sustained for at least four hours in humans and three days in rats.”
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“O’Connor hopes drinking baking soda can one day produce similar results for people with autoimmune disease.”

Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease

[Rhonda Patrick]
——–“…. women with blood levels of vitamin D in the 60 ng/ml range had an 80% lower breast cancer risk compared to women with less than 20 ng/ml.”
——–“…..men given 4,000 IU of vitamin D per day slowed cancer progression and improved tumors in men with low-grade prostate cancer (compared to men given placebo).”

Vitamin B12 levels and abnormal pap smears……
“This study aimed to explore the risk of abnormal cervical cytology in relation to serum folate and vitamin B12 levels……”
“A case-control study was carried out among women attending the gynecology clinic for cervical cytology screening.”

“103 cases with abnormal cervical cytology of the cervix and 175 controls with cytological normal smears……”

“The mean vitamin B12 level of cases was significantly lower than that of controls.”
“The results of this study suggest that lower vitamin B12 levels are associated with abnormal cervical cytology.”
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H.Yüksel, et al.
Folate and vitamin B12 levels in abnormal pap smears: a case control study.
Europpean Journal Of Gynaecological Oncology — 2007

Financial conflict among sports medicine doctors that publish research…….
“Inaccurate disclosures of physician and industry relationships in scientific reporting may create an asymmetry of information by hiding potential biases. The accuracy of conflict of interest disclosure in sports medicine research…..”

“…..financial disclosures in published articles in 2016 in the American Journal of Sports Medicine with the Centers for Medicare and Medicaid Services’ Open Payments Database to determine the percentage of payments values and percentage of eligible authors with discrepancies.”

“Stated disclosures in American Journal of Sports Medicine publications for these authors were identified and compared with industry-reported payments on Open Payments Database.”

“A total of 434 authors were included in this study. Mean and median total payments per author per year were $76,941 and $1692, respectively.”

“The most commonly received payment was for food and beverage (81.3% of authors), followed by travel and lodging (45.4%) and consulting (31.8%).”

“Authors with higher total payments were less likely to be discrepant in their reporting—notably, authors earning >$500,000 had 16.1% of payment values with discrepancy, as opposed to 85.3% for those earning <$10,000.”

“First authors had a lower percentage of payment values with discrepancy (13.8%) versus middle authors (31.9%). Finally, men had a lower percentage of payment values with discrepancy (418 authors, 22.3% of payment values with discrepancy) as compared with women (16 authors, 95.3%).”

“Regarding industry payments specifically requested on the American Journal of Sports Medicine disclosure form for authors (royalties, consulting, research payments, and ownership and investments)……25.3% of authors had a discrepancy in these payment categories in aggregate.

“Discrepancies exist between disclosures reported by authors publishing in American Journal of Sports Medicine and what is reported in the Open Payments Database. Authors receiving lower total payments, middle authors, and women are more likely to have disclosure discrepancies.”

“Additionally, industry research funding support and ownership interest are most likely to go unreported.”

V.Boddapati, et al
Accuracy Between AJSM Author-Reported Disclosures and the Centers for Medicare and Medicaid Services Open Payments Database
American Journal Of Sports Medicine — Volume 46 #4 — March 2018 — page 969

“Aerobic exercise training……can reduce migraine days and improve retinal microvascular function. Our aim was to elucidate whether different aerobic exercise programs at high vs moderate intensities distinctly affect migraine days as primary outcome and retinal vessel parameters as a secondary.”

In this randomized controlled trial, migraine days were recorded by a validated migraine diary in 45 migraineurs of which 36 (female: 28; age: 36 completed the training period (dropout: 20%).”
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Participants were assigned to either high intensity interval training, moderate continuous training, or a control group.”
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“Intervention groups trained twice a week over a 12‐week intervention period.”
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“Overall, moderate migraine day reductions were observed .12): high intensity interval training revealed 89% likely beneficial effects compared to moderate continuous training and control group.”
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“High intensity interval training seems more effective for migraine day reduction and improvement of cerebrovascular health compared to moderate continuous training. Intermittent exercise programs of higher intensities may need to be considered as an additional treatment option in migraine patients.”
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H.Hanssen, et al
Effects of different endurance exercise modalities on migraine days and cerebrovascular health in episodic migraineurs: A randomized controlled trial
Scandinavian Journal Of Medicine & Science in Sports — Volume 28 #3 — March 2018 — page 1103

“……studies have consistently shown associations between elevated concentrations of urban particulate matter air pollution and exacerbations of asthma and chronic obstructive pulmonary disease, which are both associated with viral respiratory infections.”
’……little work has focused on CD8 T‐lymphocyte responses despite their importance in anti‐viral immunity. To address this, we examined the effects of urban particulate matter on DC‐stimulated naive CD8 T‐cell responses.”
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“These data demonstrate that urban particulate matter treatment of mDCs enhances priming of naive CD8 T lymphocytes and increases production of pro‐inflammatory cytokines.”
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“Such urban particulate matter‐induced stimulation of CD8 cells may potentiate T‐lymphocyte cytotoxic responses upon concurrent airway infection, increasing bystander damage to the airways.”
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P.E.Pfeffer, et al
Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes
Immunology — Volume 153 #4 — April 2018 — page 502

“Lithium in tap water was previously found to have life-extending effects across 18 Japanese municipalities. Using a larger dataset with several Texas counties, our study shows that lithium concentrations in tap water are negatively associated with all-cause mortality and years of potential life lost.”
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“Thus, our present findings extend and reinforce lithium’s purported life-prolonging effect in humans.”
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“Lithium is an essential trace element that is most commonly known for its use in treating bipolar disorder, albeit at relatively high doses (900–1200mg per day) where adverse events including renal damage, thyroid disorders, and gastrointestinal disturbances have been observed. At much lower doses, lithium acts as a nutrient exerting positive effects not only on mental health but also on cognitive function.”
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“…..the effects of trace lithium on lifespan are impressive since the concentrations of lithium in water can be 1000-fold less than the therapeutic doses used for bipolar disorder.”
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“Here, we examined the association between trace lithium and all cause-mortality with a much larger dataset using data readily obtained from 234 counties in Texas, United States. We also examined the association between trace lithium and premature death as indicated by years of potential life lost.”

“….our study is observational and ecological in its design, and therefore a causal link between lithium exposure and reduced mortality may not be established. Although life-long intervention studies in humans may not be feasible, our study enhances the generalizability of the findings from Zarse et al. (2011), and reinforces the notion that lithium may extend lifespan in humans.”
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“….lithium is a well-known inhibitor of glycogen synthase kinase 3, and glycogen synthase kinase 3 inhibition has been shown to be required for lithium’s life-prolonging effects…..”
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“….low-dose lithium treatment also alters histone methylation, chromatin remodelling, and mitochondrial turnover, which can all influence longevity…..”
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V.A.Fajardoab, P.J.LeBlancab, V.A.Fajardoc
Trace lithium in Texas tap water is negatively associated with all-cause mortality and premature death
Canadian Journal of Applied Physiology, Nutrition, and Metabolism – Volume 43 #4 – April 2018

from the Journal Of The American Medical Association……
“Increased frequency of sauna bathing is associated with a reduced risk of sudden cardiac death, fatal coronary heart disease, fatal cardiovascular disease, and all-cause mortality.”
“We performed a prospective cohort study of a population-based sample of 2315 middle-aged (age range, 42-60 years) men from Eastern Finland.”
“……median follow-up of 20.7 years (interquartile range, 18.1-22.6 years)”
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“A traditional Finnish sauna has dry air (humidity 10%-20%) with a relatively high temperature. The recommended temperature for a sauna is usually 80°C to 100°C at the level of the bather’s face. Humidity is temporarily increased by throwing water on the hot rocks of the sauna heater.”
“Men were divided into groups on the basis of the frequency of sauna bathing (1, 2-3, and 4-7 times per week) and the duration of a sauna bathing session (less than 11 minutes, 11-19 minutes, and greater than 19 minutes).”
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Facebook friends research scientist Rhonda Patrick and husband Daniel in San Diego, Calfornia own the “Found My Fitness” website. Via their website they proliferate free, empowering research information in nutrition medicine and health via video of Rhonda’s lectures as well as her extensive interviews of leading researchers.
 
Rhonda went to Finland, interviewed the author of the sauna study. Her podcast episode……..

Facebook friends research scientist Rhonda Patrick and husband Daniel in San Diego, Calfornia own the “Found My Fitness” website. Via their website they proliferate free, empowering research information in nutrition medicine and health via video of Rhonda’s lectures as well as her extensive interviews of leading researchers……..
[Rhonda Patrick PhD]—“A new study found that using the sauna was associated with a decrease in a biomarker of inflammation (CRP) in a dose-dependent manner. The more frequent the sauna use…the more robust the effect of lowering inflammation. This study was published early this year from with one of the world’s leading sauna researchers, Dr. Jari Laukkanen.”
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“To learn more about the effects of using the sauna on human health check out my podcast with Dr. Jari Laukkanen”:
https://www.foundmyfitness.com/episodes/jari-laukkanen
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[study]—–“Using the sauna 2-3 times per week (20 minutes at 174º F) was associated with: 27% lower cardiovascular disease risk, 24% lower all-cause mortality, and a 20% lower risk of Alzheimer’s disease compared to men that only used the sauna one time per week. Using the sauna 4-7 times per week (20 minutes at 174º F) was associated with: 50% lower cardiovascular disease risk, 40% lower all-cause mortality, and a 66% lower risk of dementia and a 65% lower risk of Alzheimer’s disease compared to men that used the sauna once a week.”

TheETG menu’s 4 vegetables;
Broccoli, cucumber, carrot, Romano tomato
To increase delivery of fat soluble substances contained in these vegetables I add a source of fat via Australian macnut oil poured on top of the vegetables. Contains minerals and essential fats.

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“When tomatoes and broccoli are eaten together, we see an additive effect. We think it’s because different bioactive compounds in each food work on different anti-cancer pathways…”
[John Erdman, Professor of Food Science, University of Illinois]
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Placing mechanical or physical stress [ie. cutting them, then chewing them] activates plant chemicals contained in them, increasing their impact on brain cells, immune system, and other cells in the body.
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iso-thio-cya-nates, sulforaphane……activate specific genes in our cells for anti-oxidant enzymes and detoxifying enzymes, most of them referred to collectively as Phase 2 enzymes. Believed to be among the main mechanisms by which certain vegetables have the ability to prevent cancer and heart disease. Aside from supplying anti-oxidants in the vegetables themselves they have this ability to cause cells in our body to produce other anti-oxidants as well.
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“Sulforaphane, one of the most important isothiocyanates in the human diet, present in cruciferous vegetables, is known to have chemopreventive activities in different tissues.”

“The observed Sulforaphane-induced upregulation of phase II enzymes was accompanied by a significant increase in nuclear erythroid 2 p45-related factor 2 expression and correlated with a significant increase in total antioxidant capacity…..”

M.Malaguti, et al
Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats
Journal Of Applied Physiology…….Volume 107……August 2009……page1028

 

symptoms of Alzheimer’s –vs– fat soluble form of vitamin B1
Terms…..
— Mini-Mental Status Examination = measurement of cognitive function.
Maximum score is 30 points.
Score of 20 to 24 suggests mild dementia,
Score of 13 to 20 suggests moderate dementia,
Score of 12 and below indicates severe dementia.
The score of a person with Alzheimer’s declines 2 to 4 points each year

— benfotiamine = a fat soluble form of the water soluble B vitamin called Thiamine, also known as Vitamin B1, has better bioavailability than thiamine, and does better at getting into the brain

background info…..
Xiaoli Pan, et al. Zhongshan Hospital, Shanghai, China……..
—– “A disturbance of brain glucose metabolism is one of the most important pathophysiological features, and precedes the overt symptoms of Alzheimer’s disease by decades…..”
—– “Both the Thiamine diphosphate level and the activity of Thiamine diphosphate-dependent enzymes are significantly reduced in blood and brain autopsy samples from Alzheimer’s disease patients….Thiamine diphosphate reduction is a significant biomarker for Alzheimer’s disease diagnosis……disruption of thiamine metabolism directly contributes to Alzheimer’s disease pathogenesis by perturbing glucose utilization and by activating multiple pathophysiological cascades in the brain.”
—– “The better bioavailability and the pharmacological effects via multiple mechanisms against abnormal glucose metabolism and its consequences may explain why benfotiamine administration but not thiamine supplementation had a long-term beneficial effect on cognitive ability in Alzheimer’s disease patients.”
—– “befotiamine has beneficial effects against abnormal glucose metabolism and its consequences via multiple mechanisms, including the elimination of oxidative stress and the inhibition of glycogen synthase kinase-3, which are both considered to be major pathogenic factors that cause neurodegeneration in Alzheimer’s disease“

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“Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with Alzheimer’s disease.”
“Five patients with mild to moderate Alzheimer’s disease received oral benfotiamine (300mg daily) over 18 months.”
“All patients received oral benfotiamine (300mg/day; Doctor’s Best, Irvine, California) over 18 months.”

“All patients were examined by positron emission tomography with Pittsburgh compound B (PiB-PET) and exhibited positive imaging with β-amyloid deposition, and three received PiB-PET imaging at follow-up.”
“The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination with an average increase of 3.2 points at month 18 of benfotiamine administration.”

“The three patients who received follow-up PiB-PET had a 36.7% increase in the average standardized uptake value ratio in the brain compared with that in the first scan. Importantly, the MMSE scores of these three had an average increase of 3 points during the same period. Benfotiamine significantly improved the cognitive abilities of mild to moderate Alzheimer’s disease patients independently of brain amyloid accumulation.”

“These results indicate that brain dysfunction may be independent of amyloid deposition and that the disease progression can be halted in the dementia stage of Alzheimer’s disease.

“Our study showed that Alzheimer’s disease patients with mild-to-moderate dementia manifested a long-term (over 18 months) improvement in cognitive ability after benfotiamine administration, despite the progressive exacerbation of brain amyloid accumulation as evaluated by PiB-PET scans.”

“These results reveal two important messages: (1) the progression of brain dysfunction in the dementia stage of Alzheimer’s disease can be halted and even improved
(2) the alteration of cognitive capability is independent of brain amyloid accumulation, which is consistent with previous results showing that the reduction of brain amyloid accumulation by vaccines, antibodies, or β- and γ-secretase inhibitors has little beneficial effect on the cognitive ability and disease progression….”

Xiaoli Pan, et al
Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease
Neuroscience Bulletin – Volume 32 #6 – December 2016 – page 591

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one of the National Institutes of Health funded clinical trials in the United States…….
Gary Gibson PhD, Burke Medical Research Institute, White Plains, New York
https://www.burke.org/blog/2017/2/now-recruiting-participants-for-dementia-trial/104
https://www.nia.nih.gov/alzheimers/clinical-trials/benfotiamine-alzheimers-disease
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supplement used in this study $14 on amazon
https://www.amazon.com/gp/product/B006HW5J9C/ref=ox_sc_act_title_1?smid=ATVPDKIKX0DER&psc=1

“Low levels of vitamin D were recorded among patients with breast cancer compared with healthy controls. Moreover, low vitamin D levels were common at breast cancer diagnosis and were associated with a poor prognosis; about 94% women with vitamin D level less than 20 ng/mL develop metastases and 73% die of the advanced disease.”

“….retrospective and prospective epidemiologic studies revealed that vitamin D deficiency is associated with increased breast cancer risk.”

M.Atoum, F.Alzoughool
Vitamin D and Breast Cancer: Latest Evidence and Future Steps
Breast Cancer: Basic And Clinical Research – December 20, 2017

 



“…..vitamin D deficiency may account for several thousand premature deaths from colon, breast, ovarian, and prostate cancer annually.”

C.F.Garland, et al
The Role of Vitamin D in Cancer Prevention
American Journal Of Public Health – Volume 96 #2 – February 2006 – page 252



“….a new study correlates breast cancer survival rates with levels of vitamin D “
“Some studies have suggested that the active metabolite of vitamin D – known as calcitriol – may be anticancerous. Administering calcitriol in mice has been shown to stop the proliferation and growth of cancer cells, reduce tumor blood vessel formation, and stimulate cell death……..some clinical and preclinical studies indicate that avoiding vitamin D deficiency and taking vitamin D supplements might be a cost-effective and safe way to prevent cancer and improve prognosis in patients already diagnosed with the illness.”

“A new study led by Dr. Song Yao, from the Roswell Park Cancer Institute in Buffalo in New York, analyzed data from 1,666 women diagnosed with breast cancer…….The average age of the patients monitored was 58.7 years. Overall, half of the patients were vitamin D deficient……”

“Researchers found a lower level of the vitamin D biomarker in women with advanced-stage tumors.”

Lower levels of 25OHD were associated with higher tumor stage and grade, and women with the highest levels of 25OHD had higher survival rates overall. Levels of 25OHD also increased proportionally with vitamin D dietary and supplemental intake.”

“Our findings provide compelling observational evidence for inverse associations between vitamin D levels and risk of breast cancer progression and death….”

“The lowest levels were found in premenopausal women with triple-negative cancer. Triple-negative breast cancer is a type of cancer that tests negative for estrogen receptors, progesterone receptors, and HER2 protein.”

A.Sandoiu
Vitamin D may increase survival for breast cancer patients
Medical News Today – Thursday November 10, 2016

“Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. We aimed to prospectively examine individual and joint associations of low muscle mass and low muscle strength with all-cause mortality in a nationally representative sample.”

“This study included 4449 participants age 50 years and older……”

“Overall, the prevalence of low muscle mass was 23.1%…..and the prevalence of low muscle strength was 19.4%.”

“…..all-cause mortality was significantly higher among individuals with low muscle strength, whether they had low muscle mass or not. In addition, the significant associations between low muscle strength and all-cause mortality persisted across different levels of metabolic syndrome….”

“Low muscle strength was independently associated with elevated risk of all-cause mortality, regardless of muscle mass, metabolic syndrome, sedentary time……among US older adults, indicating the importance of muscle strength in predicting aging-related health outcomes in older adults.”

R. Li, et al
Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults
Medicine & Science in Sports & Exercise – Volume 50 #3 – March 2018 – page 458

 

TheETG mechanisms of aging —–
http://theetgtrackclub.com/documents/TheETGmechanismsaging.pdf
 
TheETG exercise program —–
http://theetgtrackclub.com/documents/TheETGexerciseprogram.pdf
 

Military recruits weight & fitness issues, not just in the United States……..
“The purpose of the present study was to investigate changes in physical fitness and anthropometry of young men entering the military service in Finland during the years 1975–2015. The study included the fitness test results of 627,142 healthy young male conscripts (age 19.1 ± 0.4 years old).”

“….the increase in mean body mass of young men has slowed down during the last 10 years. However, the total increase in body mass was 6.8 kg between 1993 and 2015.”

The mean distance achieved in the 12-minute running test decreased…..between the peak in 1980 and 2015.”

The relative number of conscripts who ran less than 2200m increased……between 1980 and 2015, and the proportion who ran more than 3000 m decreased from 25.1% to 6.5%.”

“The relative number of conscripts who achieved an excellent or good muscle fitness index decreased from 66.8% to 40.1% between 1992 and 2000, and remained unchanged between 2000 and 2010. However, the proportion who achieved a poor muscle fitness index increased from 8.1% to 31.4% between 1992 and 2010.”

The present study shows……their aerobic capacity has still decreased during recent decades. In addition, the proportion of conscripts with poor muscle fitness has increased. From the national defense and health perspective, more initiatives are needed to encourage young men to increase their level of daily physical activity to be fit and ready for operations.”

M.Santtila, et al
Physical Fitness in Young Men between 1975 and 2015 with a Focus on the Years 2005–2015
Medicine & Science in Sports & Exercise – Volume 50 #2 – February 2018 – page 292

“Results from recent studies suggest that improved diet quality……was associated with reductions of 8% to 22% in the risk of death from any cause and reductions of 19% to 28% in the risk of death from cardiovascular disease and 11% to 23% in the risk of death from cancer.”

“Here, we evaluated the association between 12-year changes (from 1986 through 1998) in the three diet-quality scores noted above and the subsequent risk of total and cause-specific death from 1998 through 2010 among participants in the Nurses’ Health Study and the Health Professionals Follow-up Study.”

“….total and cause-specific mortality among 47,994 women in the Nurses’ Health Study and 25,745 men in the Health Professionals Follow-up Study from 1998 through 2010.”

“Among participants who maintained a high-quality diet over a 12-year period, the risk of death from any cause was significantly lower — by 14% when assessed with the Alternate Healthy Eating Index score, 11% when assessed with the Alternate Mediterranean Diet score, and 9% when assessed with the DASH score — than the risk among participants with consistently low diet scores over time.”

“Improved diet quality over 12 years was consistently associated with a decreased risk of death.”

M.S.Prieto, et al
Association of Changes in Diet Quality with Total and Cause-Specific Mortality
New England Journal Of Medicine – Volume 377 #2 – July 13, 2017 – page 143

“Type 2 diabetes is characterized by reductions in β-cell function and insulin secretion on the background of elevated insulin resistance. Aerobic exercise has been shown to improve β-cell function, despite a subset of Type 2 diabetes patients displaying “exercise resistance”. Further investigations into the effectiveness of alternate forms of exercise on β-cell function in the Type 2 diabetes patient population are needed.”

“We examined the effect of a novel, 6-weeks CrossFit functional high-intensity training intervention on β-cell function in 12 sedentary adults with clinically diagnosed Type 2 diabetes (54 years old).”

“Supervised training was completed 3 days/week, comprising functional movements performed at a high intensity in a variety of 10- to 20-minute sessions.”

“The mean disposition index, a validated measure of β-cell function, was significantly increased after the intervention. Insulin processing inefficiency in the β-cell, expressed as the fasting proinsulin-to-insulin ratio, was also reduced. Increased β-cell function during the early-phase response to glucose correlated significantly with reductions in abdominal body fat and fasting plasma alkaline phosphatase.”

“Mean total body-fat percentage decreased significantly, whereas lean body mass was preserved. We conclude that functional high-intensity training is an effective exercise strategy for improving β-cell function in adults with Type 2 diabetes.”

S.Nieuwoudt, et al
Functional high-intensity training improves pancreatic β-cell function in adults with type 2 diabetes
American Journal Of Physiology: Endocrinology & Metabolism – Volume 313 #3 – September 2017 – page E314

“Dietary fish oils, rich in long-chain n–3 fatty acids [e.g., docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)], modulate inflammatory reactions through various mechanisms, including gene expression, which is measured as messenger RNA concentration.”
“We wanted to determine the effects of 6 months of dietary supplementation with an n–3 FA preparation rich in DHA on global DNA methylation of peripheral blood leukocytes and the relation to plasma EPA and DHA concentrations in Alzheimer disease patients.”

“Patients originated from the randomized, double-blind, placebo-controlled OmegAD study, in which 174 Alzheimer patients received either 1.7g DHA and 0.6g EPA or placebo daily for 6 months.”

“At 6 months, the n–3 FA group displayed marked increases in DHA and EPA plasma concentrations (2.6- and 3.5-fold), as well as decreased methylation in 2 out of 4 CpG sites, respectively.”

“Supplementation with n–3 FA for 6 months was associated with global DNA hypomethylation in peripheral blood leukocytes. Our data may be of importance in measuring various effects of marine oils, including gene expression, in patients with Alzheimer disease and in other patients taking n–3 FA supplements.”

K.Mohsen, et al
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
American Journal Of Clinical Nutrition — Volume 106 #4 — October 2017 — page 1157

“Practices that include yoga asanas and mindfulness-based stress reduction for the management of stress are increasingly popular……”
“……systematic review and meta-analysis of randomised controlled trials….”
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“42 studies were included in the meta-analysis.”
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“Interventions that included yoga asanas were associated with
– reduced cortisol, systolic blood pressure, heart rate, heart rate variability
– reduced fasting blood glucose, cholesterol and low density lipoprotein.
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“Practices that include yoga asanas appear to be associated with improved regulation of the sympathetic nervous system and hypothalamic-pituitary-adrenal system in various populations.”
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M.C.Pascoe, et al
Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis
Psychoneuroendocrinology — Volume 86 — December 2017

Alzheimer’s, Heart Disease, Cancer……
Medically the 3 big ticket items in America. Fewer than 10% of people that get these are in an “its genetic” situation. Medically the 3 big ticket items in America all have the immune system in common……
— In Alzheimer’s….macrophages are a specific type of immune system cell that are supposed to remove beta-amyloid plaques from brain blood vessel walls, preventing beta-amyloid’s continued accumulation and toxicity to brain cells, especially those in the memory areas of the brain called the hippocampus.

— In Heart Disease….macrophages are a specific type of immune system cell that are supposed to remove cholesterol plaques from blood vessel walls, preventing their continued accumulation and significant blocking of blood flow through blood vessels.

— In cancer…”Natural killer cells” are a specific type of immune system cells that are supposed to kill cancer cells, preventing their continued growth and spread. At autopsy, many Americans that died of Alzheimer’s were developing heart disease and cancer. At autopsy, many Americans that died of Heart Disease were developing Alzheimer’s and cancer. At autopsy, many Americans that died of cancer were developing Alzheimer’s and cancer.

— In the brain, when rate of beta-amyloid deposits exceeds the rate of removal, and does so for years or decades, this is what Alzheimer’s looks like.

— In the blood vessels around the heart, legs, neck, etc, when rate of cholesterol deposits exceeds the rate of removal, and does so for years or decades, this is what Heart Disease looks like.

— In the body in general, when rate of cancer cell production, growth, and/or spread exceeds the rate of cancer cell death, and does so for years or decades, this is what Cancer looks like.

To be a good doctor one must -first- be a good physiologist. Physiology is -not- pharmacology. You can’t drug your way to a fully functioning immune system. You can’t drug your way to restore an immune system to full functioning.

TheETG repair of brain cell overwork, overwhelm, “mental illness” —– http://theetgtrackclub.com/documents/TheETGbrain.pdf

Rather than focus on the removal of beta-amyloid plaques in the brain by macrophages, the Traditional Medicine approach is to drug their way to artificially upping neurotransmitters related to memory and thinking ability to help people ‘live with” beta amyloid continuing to kill off their brain cells.
Rather than focus on the removal of choloesterol plaques by macrophages, the Traditional Medicine approach is to drug [via statin drugs….Lipitor, Crestor, Pravastatin, etc] their way to slowing the rate that cholesterol plaques continue to accumulate on blood vessels walls, continuing to close off the blood vessel and kill patient.
Rather than focus on the killing of cancer cells by Natural Killer cells, the Traditional Medicine approach is to drug and radiate their way to temporarily killing some cancer cells while also killing off the body’s main killers of cancer cells, sending the patient on their way with a low functioning immune system and the likelihood of recurrence in spite of the “cancer survivor” mantra.
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— Relatively modest levels of immune system suppression maintained over years or decades can have major effects. It can be enough to create a situation where…..beta amyloid’s binding of a small amount of a substance called “macrophage-inhibitory factor” can be all that’s necessary for Alzheimer’s progression across years and decades.

— Relatively modest levels of immune system suppression maintained over years or decades can have major effects. It can be enough to create a situation where…..a small amount of cholesterol causing engorgement of macrophages rendering them useless can be all that’s necessary for Heart Disease progression across years and decades.

— Relatively modest levels of immune system suppression maintained over years or decades can have major effects. It can be enough to create a situation where…..cancer cell production of a small amount a substance called “Inter-Leukin-10”, preventing Natural Killer cells from killing them off can be all that’s necessary for Cancer progression across years and decades. To be a good doctor one must -first- be a good physiologist. Physiology is -not- pharmacology. Mind-Body Medicine is all but exclusively about using the brain to increase immune cell number, immune cell activity, and restore immune system functioning. Through published research, Nutrition Medicine has identified several individual nutrients that can be consumed in supplement form to increase immune cell number, immune cell activity, and restore immune system functioning. The immune system…..Chronically elevated levels of stress, levels maintained for years or decades chronically reduces immune cell number, immune cell activity, immune system functioning. Stress leads to increased production of beta-amyloid, increased deposits of cholesterol on blood vessel walls, increased production of cancerous cells.
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Through published research, Nutrition Medicine has identified several individual nutrients that can be consumed in supplement form that interfere with beta amyloid production or its continued existence. Such as resveratrol. Such as curcumin. Such as N-acetyl-L-cysteine. Such as L-Carnitine.
Through published research, Nutrition Medicine has identified several individual nutrients that can be consumed in supplement form that interfere with cholesterol getting deposited on artery walls or aid in its removal. Such as Vitamin K2. Such as Allicin [Kyolic]. Such as Resveratrol.
Through published research, Nutrition Medicine has identified several individual nutrients that can be consumed in supplement form that can increase Natural Killer Cell activity and function in killing cancer cells. Such as liquid colostrum. Such as very long chain plant sugars [organic Aloe Juice]. Such as nucleotides.
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To be a good doctor one must -first- be a good physiologist.
Physiology is -not- pharmacology.

“All the good things….they don’t teach us in medical school, because the drug companies pay for our education.” [Dr. John Sessions M.D.]

“……the benefits that US health care currently deliver may not outweigh the aggregate health harm it imparts.” [Journal Of The American Medical Association…Volume 302 #1..July 1, 2009…page 89 – 91] “In the United States, 50% of people over age 85 will develop Alzheimer’s disease” [CEO of the Alzheimer’s Foundation Of America]

Meditation or relaxation exercises.
The memory, thinking, and reasoning areas of the brain are no different than muscle. Decades of stress and overwork will present its bill at some point.

Exercise the brain.
The memory, thinking, and reasoning areas of the brain are no different than muscle. Atrophy due to disuse will eventually create a breeding ground for oxidants and pro-oxidants that will attack tissues and DNA, leading to several disease processes, from clogged blood vessels [stroke] to altered cell production [cancer]. This is more than “use it or lose it”. You’ll not only lose it if you don’t use it, but you’ll contribute to disease if you don’t use it.

Exercise the brain.
The brain controls muscle. Walking, running, lifting weights, ect, don’t just exercise muscles and heart, they exercise the brain cells as well. Atrophy due to disuse [ie. lack of exercise] will eventually create a breeding ground for oxidants and pro-oxidants that will attack tissues and DNA, leading to several disease processes, from clogged blood vessels [stroke] to altered cell production [cancer]. This is more than “use it or lose it”. You’ll not only lose it if you don’t use it, but you’ll contribute to disease if you don’t use it.

“The term hidden elder is used in Chinese society to describe older adults who are socially isolated and refuse social participation. Substantial evidence has indicated the important role of social isolation in increasing psychiatric morbidity and mortality risks in later life.“
 
”Innovative service is promptly needed to address the social and psychological health needs of hidden elders. We aimed to test the feasibility and the preliminary effectiveness of a peer-assisted tai-chi-qigong programme in strengthening social networks and enhancing psychosocial wellbeing of Chinese hidden elders.”
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”In the 3-month tai-chi-qigong programme, participants practiced two 60-min sessions each week, during which they were paired up with socially active older adults.“
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”Participants who received the peer-assisted tai-chi-qigong programme generally showed better improvement in outcomes than the control group. With support from peer elders, the compliance rate of elders participating in tai-chi-qigong was 71%.”
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“This pilot study showed that peer-assisted tai-chi-qigong is a feasible social intervention for hidden elders. A full-scale trial is needed to assess the possible benefits for social and physical health.”
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A.W.K.Chan, et al
Effects of a peer-assisted tai-chi-qigong programme on social isolation and psychological wellbeing in Chinese hidden elders: a pilot randomised controlled trial
The Lancet — Volume 388, Supplement 1 — October 2016, Page S23
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“This study included 18,676 adults aged 80–122 years from the Chinese Longitudinal Healthy Longevity Survey…..”
“In a large sample of Chinese oldest old, we found a dose-response association between psychological wellbeing and all-cause mortality. Our results, if substantiated by future research, suggest that psychological factors in older age might have a role in longevity.”
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E.Gong, et al
Psychological wellbeing and all-cause mortality in the oldest old in China: a longitudinal survey-based study
The Lancet — Volume 388, Supplement 1 — October 2016, Page S22

Weight Loss
The beginning of getting control over your food consumption………
— Give away or throw away the plates you have today.
— replace the plates you use with plates that are –no larger– than 6 to 7 inches across
— eat out one fewer time per week.
— at fast food places, move away from the large drinks, get the small drink plus a water.
— Binge eating….if you binge on snack foods several times per week [or per day] focus on stopping –one- of them
— Binge eating….focus less on how much you’re eating and more on aggressively getting to the bottom of “what’s eating you”.
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“Begin with the end in mind”
[Stephen Covey]
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The greatest act of self-sabotage is to engage in dieting. For example….
— person X weighs 250, wants to weigh 200
— person X diets and thus eats like someone that weighs 120, rather than someone that weighs 200.
— person X losses weight
— person X gradually discovers he/she can’t keep eating like a 120 pound person forever
— person X stops the diet and regains the weight that was lost, plus a few more pounds
Begin with the end in mind. If you want to weigh 200 then eat like you will eat when you weigh 200 pounds.
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Perform This Task
Visit an antique shop. Look at the standard plate size in the1920’s – 50’s. Compare them to what you have in your kitchen cabinets today. The first thing that goes through people’s minds when they go to smaller plates is….”how do I fit all my food on such a small plate”. That’s pretty much the point. You don’t fit [and can’t] fit all the volume of food you’re accustomed to eating on the small plate.
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Update Your Brain’s Programming
Adopt the self-image and life style of the person you want to be. Take advantage of the brain and its ability to be programmed.
Write sentences of positive Affirmations. Use Visualizations….”The me I see is the me I’ll be”.

Nutrition 101
Low fat diets are -not- your friend.
All fats are -not- created equal…..
— good = animal & nuts = grass fed beef, cold water fish, fish oil, mac nut oil
— bad = vegetable oils = corn oil, canola oil, soybean oil, etc
— ugly = from heavily processed foods = potatoe chips, etc
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Refrigerators and freezers.
Americans have gone off the rails.
Refrigerators and freezers being used, not to slow or prevent food decay, but for avoiding trips to the grocery. Stocking food for consumption, not for 24 – 72 hours as was the ballpark original intent of the technological advance in our culture but for 3 to 4 weeks or 3 to 4 months.
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Nutrients in foods aren’t permanent fixtures. Those supposed healthy nutrient dense foods sitting in your fridge on day 6 or day 16. The nutrient content on day 6 isn’t the same as that on day 2 or day 3. The nutrient content of that stuff in the freezer isn’t the same on week 3 as it was on day 3.
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Lets all agree to pull back a bit.
If you own a car and you’re not a chef cooking for the Brady Bunch every day and night, lets get some empty space in that fridge and in that freezer. On the doors, on the top racks. Lets return to using the appliance primarily for something in the ballpark of the original intent back in the day, forcing us all to consume more nutrients, less food, and engage in less gluttony.
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Lets get away from the “Costo buy in bulk” mentality in food purchases. Lets leave that for toilet paper and paper towels. When it comes to the stuff we put into our bodies lets head in a different direction.
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Buy it today, eat it today or tomorrow or the next day. Not next week or next month.
Cook it tomorrow, eat it tomorrow or the next day. Not next week or next month.
The goal is “paltry”.
The word you want somebody to come closest to when they open your refrigerator and freezer doors and describe what they see…..as opposed to OMG!.
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“Eating well”.
If you grew up in America and want to move into the realm of “eating well”, or eating better, or eating “healthy”, you are at some point going to have to confront and overcome the cultural dogma you were indoctrinated into. The purpose here being to provide you with a clean slate from which to get started learning how to “eat well”.
Cultural dogma #1 = Breakfast, lunch, and dinner. The cultural dogma of “3 square meals a day”, each with a designated time frame. Ya gotta lose this.
Cultural dogma #2 = Each meal has to be comprised of a balanced consumption of food items from a set of identified food groups. Ya gotta let this go too.
Cultural dogma #3 = Food item X is a “breakfast” food, not to be consumed outside the designated time frame. Food item Z is a dinner food, not to be consumed outside the designated time frame.
Cultural dogma #4 = all snack foods, desert foods, and psuedo-meal foods are the same…..They’re all “junk foods”.
Reality…..food items such as organic thin crust “supreme” pizzas are among –the– most nutrient dense food items known to man.
Reality…..food items such as organic apple pie, organic cheese cake contain extraordinarily high levels of cell–necessary poly and mono unsaturated fatty acids, essential for brain function, immune cell function, and for production and repair of cell membranes throughout the human body.
In the quest to “eat well” its necessary to put data ahead of dogma.

Avoiding so-called “junk foods” that are packed with nutrients won’t help you eat well. Avoiding some foods in the evening because they’re “breakfast foods” won’t help you eat well. Avoiding some foods in the morning because they’re “dinner foods” won’t help you eat well.
To “eat well” you’re gonna have to remove the artificial, culturally indoctrinated time of day designations from food items.
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Not all fats are the same.
Eating “a low fat diet” is more likely to prevent you from consuming required levels of essential fats than it is to help you with weight loss or maintaining weight loss…..and more likely to contribute to long term health problems that will begin showing up in no uncertain terms in your 50’s and 60’s.
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The word “calorie” has no place in human nutrition.
Your cells don’t care about how many calories you consume.
They don’t care about what percentage of the food you consume is comprised of fat, protein, or carbohydrate.
They care about grams, milligrams, micro-grams, nano-grams of nutrients.
And they don’t do averages…..X calories per day. They do absolutes.
The cells of your body need what they need when they need it.
Today’s needs are not tomorrow’s or last week’s.
Learn to think and reason in these terms.
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Once you’ve deleted the dogma, creating a standardized nutrient dense written food plan that repeats every few days may prove to be the easiest approach to truly getting started “eating well”, eating better, eating “healthy”.

 

The “medicare for everybody” proposal.
Lets do the math.
Today we spend over $3 trillion each year, about $10,000 per person.
“Medicare for everybody” is projected to cost about $1.5 trillion each year.
Today we give about $1 trillion each year to insurance companies.

We spend $350 billion out of pocket.
That would likely go unchanged by a “medicare for everybody” approach as many wealthy folks would likely continue to do as they please.
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Combined medicare + medicaid we spend about $1 trillion each year.
We spend about $20,000 per year, per person over age 65.
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Pretty easy to assert that spreading the cost across more payers is a logical long term approach. Like social security, folks that can afford to do as they please can continue to do as they please.
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Prior to asserting that there’ll be an increase in a wait times to see a doctor one should examine the –current– state of things today. Before citing issues in Canada, look at what happens here, particularly in states that have doctor shortages. There’s a reason we’ve been literally importing doctors from other countries.

Save talk radio talking points for talk radio.
They have no place in a reality based, fact based discussion about healthcare in America.

“Increases in C-reactive protein from childhood to adolescence predict sleep apnea in adolescence.”
“Increased waist circumference correlates with C-reactive protein increases in boys.”

“During adolescence, boys develop more central adiposity than girls.”

“Inflammation mediates the association between waist circumference and apnea severity.”
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J.Gaines, et al
Increased inflammation from childhood to adolescence predicts sleep apnea in boys: A preliminary study
Brain, Behavior, and Immunity — Volume 64 — August 2017 — page 259

My FDA warning of the week
[July 9, 2015]…..”The U.S. Food and Drug Administration is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs increase the chance of a heart attack or stroke.”

“Examples of nonsteroidal anti-inflammatory drugs include ibuprofen, naproxen, diclofenac, and celecoxib.”

“Patients taking nonsteroidal anti-inflammatory drugs should seek medical attention immediately if they experience symptoms such as chest pain, shortness of breath or trouble breathing, weakness in one part or side of their body, or slurred speech.”

“The risk of heart attack and stroke with nonsteroidal anti-inflammatory drugs, either of which can lead to death, was first described in 2005 in the Boxed Warning and Warnings and Precautions sections of the prescription drug labels.”

“Patients and health care professionals should remain alert for heart-related side effects the entire time that nonsteroidal anti-inflammatory drugs are being taken. We urge you to report side effects involving NSAIDs to the FDA MedWatch program, using the information in the “Contact FDA” box at the bottom of the page.”

Similar to spinal cord healing…re-think what you think you know.
Stroke recovery 2 decades later……
“Widespread bilateral activation of both sides of the cerebrum and cerebellum are demonstrated on functional MRI after motor recovery of a completely nonfunctional left hand that began 23 years after a severe stroke. “
“This suggests that the generally accepted window of recovery beyond which further therapy is not indicated should be entirely reconsidered.”

“Physiotherapy and new modalities in development might be indicated long after a stroke.”

“It is widely believed that most stroke recovery occurs within 6 mo, with little benefit of physiotherapy or other modalities beyond 1 yr.”

“We report a remarkable case of stroke recovery beginning 23 yr after a severe stroke due to embolization from the innominate artery and subclavian artery, resulting from compression of the right subclavian artery by a cervical rib. The patient had a large right frontoparietal infarction with severe left hemiparesis and a totally nonfunctional spastic left hand. He experienced some recovery of hand function that began 23 yr after the stroke, 1 yr after he took up regular swimming. As a result, intensive physiotherapy was initiated, with repetitive large muscle movement and a spring-loaded mechanical orthosis that provides resistance to finger flexors and supports finger extensors. Within 2 yr, he could pick up coins with the previously useless left hand.”

“Functional MRI studies document widespread distribution of the recovery in both hemispheres.”

“This case provides impetus not only to more intensive and prolonged physiotherapy, but also to treatment with emerging modalities such as stem cell therapy and exosome and microRNA therapies.”

P. Sörös, et al
Motor recovery beginning 23 years after ischemic stroke
Journal Of Neurophysiology — Volume 118 #2 — August 2017 — page 778

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from the top of the homepage of TheETG website…….

Data-less conclusions founded upon faulty assumptions are the mother of all screw-ups. They lead to human belief systems that quickly get set in stone insuring that new information gets shouted down as group think, ego, and resistance to change supplant data, logic and reason.
In all areas of applied science and particularly in anything having to do with human performance, age & aging, and “its genetic”…..avoid group think, pursue critical thinking, engage in intellectual honesty.

Put data ahead of dogma. Follow the data -not- the crowd.

“In God we trust…Everyone else must bring data.” —[W.Edwards Deming]

 

TheETG quadriplegic, paraplegic nerve repair training
http://theetgtrackclub.com/documents/TheETGnervequadpara.pdf

[fish oil + strength training for the elderly]…….
“Age-related decline in lower limb explosive strength leads to impaired ability to perform daily living tasks. The present randomized controlled trial demonstrates that a healthy diet rich in n-3 polyunsaturated fatty acid enhances resistance training-induced gains in dynamic explosive strength capacity during isolated lower limb movements and multijoint exercises in healthy elderly women.”
“This supports the use of strategies combining resistance training and dietary changes to mitigate the decline in explosive strength capacity in older adults.”

“The effects of 24 week of resistance training combined with a healthy diet on lower limb explosive strength capacity were investigated in a population of healthy elderly women.”

“Progressive resistance training was performed at a load of 75–85% one-repetition maximum.”

“In conclusion, a healthy diet rich in n-3 polyunsaturated fatty acid can optimize the effects of resistance training on dynamic explosive strength capacity during isolated lower limb movements and multijoint exercises in healthy elderly women.”

P.Edholm, E.Strandberg, F.Kadi
Lower limb explosive strength capacity in elderly women: effects of resistance training and healthy diet
Journal of Applied Physiology — Volume 123 #1 — July 2017 — page 190

 

“This study examined whether home-based, high-speed calf-raise training changes the rate of torque development during plantar flexion contractions and balance performance in elderly men.”

“The subjects in the training group completed 8 week (3 times/week) of home-based bilateral calf-raise training using body mass.”

“Our findings indicate that calf-raise training at home, performed without special equipment or venue, induces a substantial increase in the plantar flexors’ rapid force-generating capability and triceps surae activations.

“In conclusion, functional neuromuscular capacity can be enhanced by home-based calf-raise exercise in elderly men, which may protect against mobility loss with aging.”

R.Ema, et al
Effect of calf-raise training on rapid force production and balance ability in elderly men
Journal of Applied Physiology — Volume 123 #2 — page 424

[from facebook friend and research scientist Rhonda Patrick PhD]…..I’m super excited that I got my cord blood and placenta banking kit in today! Most people are familiar with banking cord blood, a source of hematopoietic stem cells which can form any blood cell type but are limited to blood cells. The placenta is not only a better source of hematopoietic stem cells because it contains 5-7 times more than cord blood, it also is a rich source of pluripotent stem cells, which are a variety of stem cells that can form cells of any other tissue type including neurons. My friend and former colleague, Dr. Frans Kuypers discovered that the human placenta was a source of pluripotent stem cells back in 2009… and yet the placenta is usually thrown away after delivery. Taking into consideration the fact that there are around 4 million live births in the United States per year alone, you’re talking about a lot of thrown away precious stem cells!

There are only a couple of companies that are currently banking placental stem cells. I decided to go with LifebankUSA (no affiliation) to bank my cord blood and placenta. I hope to see more well-established cord blood companies start banking placental tissue…it is so worth it. If you want to learn more about the placenta as a rich source of pluripotent stem cells you can listen to or watch my interview with Dr. Kuypers on iTunes or YouTube. The name of my podcast and youTube channel is called foundmyfitness. Just look for the interview with Dr. Kuypers (it is an old one).

YouTube link:
https://youtu.be/XrK5_pEUzdI

“The Patient Protection and Affordable Care Act of 2010 brought attention to adverse drug events in national patient safety efforts.”
“…..emergency department visits for adverse drug events in the United States in 2013-2014 and describe changes in emergency department visits for adverse drug events since 2005-2006.”
“…..data from 42,585 cases…..in 2013 and 2014 and 27.3% of emergency department visits for adverse drug events resulted in hospitalization.”
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“An estimated 34.5% emergency department visits for adverse drug events occurred among adults aged 65 years or older in 2013-2014 compared with an estimated 25.6% in 2005-2006; older adults experienced the highest hospitalization rates (43.6%).”
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“Anticoagulants, antibiotics, and diabetes agents were implicated in an estimated 46.9% emergency department visits for adverse drug events……”
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“Among children aged 5 years or younger, antibiotics were the most common drug class implicated. Among children and adolescents aged 6 to 19 years, antibiotics also were the most common drug class implicated (31.8%) in emergency department visits for adverse drug events, followed by antipsychotics (4.5%).”
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“Among older adults (aged ≥65 years), 3 drug classes (anticoagulants, diabetes agents, and opioid analgesics) were implicated in an estimated 59.9% emergency department visits for adverse drug events….”
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N. Shehab, et al
US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014
Journal Of The American Medical Association — Volume 316 #20 — November 22/29, 2016 — page 2115

“……the benefits that US health care currently deliver may not outweigh the aggregate health harm it imparts.”
[Journal Of The American Medical Association…Volume 302 #1..July 1, 2009…page 89 – 91]

Nutrition Medicine = food and/or supplements as medicine
fish oil for pregnant mothers…….
“Reduced intake of n−3 long-chain polyunsaturated fatty acids (fish oil) may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n−3 long-chain polyunsaturated fatty acids in pregnant women on the risk of persistent wheeze and asthma in their offspring.”
“….736 pregnant women at 24 weeks of gestation to receive 2.4 grams of n−3 long-chain polyunsaturated fatty acids (fish oil) or placebo (olive oil) per day.”

“Neither the investigators nor the participants were aware of group assignments during follow-up for the first 3 years of the children’s lives, after which there was a 2-year follow-up period during which only the investigators were unaware of group assignments.”

“……695 children were included in the trial, and 95.5% completed the 3-year, double-blind follow-up period.”

“….risk of persistent wheeze or asthma in the treatment group was 16.9%, versus 23.7% in the control group…..corresponding to a relative reduction of 30.7%.”

“…the effect was strongest in the children of women whose blood levels of eicosapentaenoic acid and docosahexaenoic acid were in the lowest third of the trial population at randomization: 17.5% versus 34.1%.”

“Analyses of secondary end points showed that supplementation with n−3 long-chain polyunsaturated fatty acids (fish oil) was associated with a reduced risk of infections of the lower respiratory tract (31.7% vs. 39.1%)….”

“Supplementation with n−3 long-chain polyunsaturated fatty acids (fish oil) in the third trimester of pregnancy reduced the absolute risk of persistent wheeze or asthma and infections of the lower respiratory tract in offspring by approximately 7 percentage points, or one third.”

Hans Bisgaard, et al
Fish Oil–Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring
New England Journal Of Medicine — Volume 375 #26 — December 29, 2016 — page 25

Buyer beware. The quackery of traditional medicine……
“Inappropriate imaging for low back pain can cause harm in three ways: Misinterpretation of results by clinicians resulting in unhelpful advice, needless subsequent investigations (downstream testing) and invasive interventions, including surgery; Misinterpretation of results by patients resulting in catastrophisation, fear and avoidance of movement and activity, and low expectations of recovery; Side effects such as exposure to radiation.”

Problems associated with excessive imaging for low back pain are well recognised and useful evidence-based guidelines have been developed to help clinicians determine when investigation is appropriate. However, currently, 42% of patients with low back pain receive an X-ray, CT or MRI within 1 year of diagnosis, and of these, 80% receive imaging within 1 month of presentation.”

“The uptake of imaging guidelines is likely to be similarly insufficient among the sports medicine community, where lumbar imaging is frequently used.”

B.Darlow, et al
It is time to stop causing harm with inappropriate imaging for low back pain
British Journal Of Sports Medicine -Volume 57 #5 — March 2017

“These media reports highlight the problem of back pain in sport. From the reports it would appear that athletes’ back symptoms are serious and linked to structural damage. Athletes appear to be managed with rest or limiting training and competition, early referral for advanced imaging that often leads to invasive treatments and a requirement that symptoms settle before full sporting participation can resume. Such an approach to management contradicts current guidelines for back pain.”

B.Darlow, P.B.O’Sullivan
Why are back pain guidelines left on the sidelines? Three myths appear to be guiding management of back pain in sport
British Journal Of Sports Medicine — November 2016 – Volume 50 #21

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TheETG back, neck, & frozen shoulder repair —– http://theetgtrackclub.com/documents/TheETGbackshoulderrepair.pdf

McKenzie Method physical therapy is –the– most effective and researched method of resolving back pain. It also empowers the patient to fix future problems should they arise, and do it on their own.
——- McKenzie Method diplomaed practitioner or McKenzie certified ….
http://www.mckenziemdt.org/method.cfm

“High intensity interval training can produce similar if not greater improvements in cardiorespiratory fitness, an independent protective factor against premature death, and some health-related parameters compared to conventional, moderate intensity continuous training.

“High intensity interval training takes substantially less time to complete and this enhances its potential in public health promotion given that lack of time is one of the barriers to long-term adherence to physical activity and exercise training.”

High intensity interval training describes exercise bouts of 10 seconds to 4 minutes with ‘all-out’ maximal effort or intensities of 85–95% of maximum heart rate interspersed by periods of low activity or rest (30 seconds to 4 minutes).

“Despite the accumulated evidence, very little improvement has been made in terms of high intensity interval training implementation in real life settings…”

G.P. Nassis
High-intensity interval training: how much pain to get a gain?
British Journal Of Sports Medicine — Volume 51 #6 — March 2017

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TheETG exercise program —– http://theetgtrackclub.com/documents/TheETGexerciseprogram.pdf

 

stretching vs heart disease [a.k.a. vascular disease, a.k.a blood vessel issues]……
“Maintenance and enhancement of vascular endothelial function contribute to the prevention of cardiovascular disease and prolong a healthy life expectancy. Given the reversible nature of vascular endothelial function, interventions to improve this function might prevent arteriosclerosis.”
“Accordingly, we studied the effects of a 6-month static stretching intervention on vascular endothelial function and arterial stiffness and investigated the reversibility of these effects after a 6-month detraining period following intervention completion.”

“The study evaluated 22 healthy, non-smoking, premenopausal women aged ≥40 years. Subjects were randomly assigned to the full-intervention (n = 11; mean age: 48.6 ± 2.8 years) or a half-intervention that included a control period (n = 11; mean age: 46.9 ± 3.6 years).”

“Body flexibility and vascular endothelial function improved significantly after 3 months of static stretching.”

“In addition to these improvements, arterial stiffness improved significantly after a 6-month intervention. However, after a 6-month detraining period, vascular endothelial function, flexibility, and arterial stiffness all returned to preintervention conditions, demonstrating the reversibility of the obtained effects.”

“A 3-month static stretching intervention was found to improve vascular endothelial function, and an additional 3-month intervention also improved arterial stiffness. However, these effects were reversed by detraining.”

H.Shinno, et al
Evaluation of a static stretching intervention on vascular endothelial function and arterial stiffness
European Journal Of Sport Science — Volume 17 #5 — 2017 — page 586

Nutrition Medicine = food and/or supplements as medicine……….
“With the numerous failures of pharmaceuticals to treat traumatic brain injury in humans, more researchers have become interested in combination therapies. This is largely due to the multimodal nature of damage from injury, which causes excitotoxicity, oxidative stress, edema, neuroinflammation and cell death.”
“Over the past 20 years, interest in supplementation and supraphysiologic dosing of nutrients for brain injury has increased and indeed many vitamins and nutrients now have a considerable body of the literature backing their use.”
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“Here, we review several of the prominent therapies in the category of nutraceutical treatment for brain injury in experimental models, including vitamins (B2, B3, B6, B9, C, D, E), herbs and traditional medicines (ginseng, Gingko biloba), flavonoids, and other nutrients (magnesium, zinc, carnitine, omega-3 fatty acids). While there is still much work to be done, several of these have strong potential for clinical therapies….”
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C.V.Haar, et al
Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapiesReview Article
Brain Research — Volume 1640 — June 2016 — page 114

“In patients with adrenal insufficiency a higher hydrocortisone intake has been associated with more impairment in quality of life.”

“Irrespective of age, sex and severity of adrenal insufficiency the dosage of hydrocortisone is titrated around 20 mg/D in all patients with adrenal insufficiency based on physical and mental signs and symptoms.”

“This study aimed to explore whether quality of life in patients with adrenal insufficiency is associated with hair cortisol and daily hydrocortisone intake. We performed a cross-sectional study in 120 patients with adrenal insufficiency on stable hydrocortisone replacement, in whom hair samples and quality of life data were collected.”

“The present study showed that patients with adrenal insufficiency report several impairments in quality of life which are associated with hydrocortisone intake, and to a lesser extent reflected by chronic systemic cortisol exposure as measured by hair cortisol.”

C.D. Andela, et al
Quality of life in patients with adrenal insufficiency correlates stronger with hydrocortisone dosage, than with long-term systemic cortisol levels
Psychoneuroendocrinology — Volume 72 — October 2016 — page 80

Christie Befort, an ex-girl friend from the mid-1990’s that I’m quite proud of.
She has close to $15 million in cancer prevention research grants from our country’s government. In the video, she presented a portion of her data at a conference last February on healthcare disparity. The conference is for the Health & Medicine division of the National Academies Of Science, Engineering, & Medicine.
She is a research professor in counseling psychology specializing in Preventive Medicine [The University of Kansas Cancer Center], and among the top researchers in the world in reversal of Obesity and by default…..prevention of cancer, especially breast cancer in women.
The bulk of her research grants are from the Patient-Centered Outcomes Research Institute [created by the “Obama Care” bill…national comparative effectiveness research program] that followed a $3 million grant from National Cancer Institute, which followed a $30,000 grant from the American Cancer Society.
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Obesity in women is highest in rural areas.
Her first study demonstrating efficacy of her protocol for weight loss and maintaining it started with some women in rural Kansas.
That study expanded to 300 women across the state.
Then it expanded to 4 states [Kansas, Nebraska, Wisconsin, Iowa].

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Traditional approach to cancer treatment. Long term outcomes……

"Tamoxifen is most commonly prescribed for patients with hormone-sensitive breast cancer and exerts agonistic/antagonistic effects on estrogen receptors throughout the body. Accumulating evidence has revealed that breast cancer patients receiving Tamoxifen manifest cognitive dysfunction."
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"In the present study, we sought to explore the attention function of premenopausal women with hormone receptor-positive breast cancer treated with Tamoxifen using the attention network test."
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"Our results indicated that patients in the Tamoxifen group had significant deficits in their executive control component but not in the alerting or orienting components. Moreover, the patients showed poor executive function performance in the neuropsychological tests. Additionally, in the Tamoxifen group, significant correlations were found between the decreased efficiency of the executive control component and their reduced performance in executive function tests."
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"This study demonstrates that premenopausal women with hormone receptor-positive breast cancer treated with Tamoxifen have impairment of the executive attention network and that this impairment was associated with differences in executive function performance."

X.Chen, et al
Impairment of the executive attention network in premenopausal women with hormone receptor-positive breast cancer treated with tamoxifen
Psychoneuroendocrinology -- Volume 75 -- January 2017 

————————————

"Cranial radiotherapy is a known risk factor for neurocognitive impairment in survivors of childhood acute lymphoblastic leukemia. Understanding the nature of cognitive dysfunction during adulthood in acute lymphoblastic leukemia survivors is important as it has an impact on major life situations."
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"38 acute lymphoblastic leukemia survivors were investigated 34 years after diagnosis."
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"Median-age was 38 (27–46) years."
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"Acute lymphoblastic leukemia survivors scored lower than controls in vocabulary, memory, learning capacity, spatial ability, executive functions and attention 34 years after acute lymphoblastic leukemia treatment."
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"Compared to controls acute lymphoblastic leukemia survivors had reduced white matter and grey matter volumes. ALL survivors had lower levels of white matter."
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"The present study shows impaired brain metabolism.....reduced brain volumes and neurocognitive impairment in childhood acute lymphoblastic leukemia survivors treated with cranial radiotherapy and chemotherapy, despite complete hormone substitution."
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"We also report an impairment of metabolites correlated to time since treatment and a progressive impairment in sustained attention, suggesting an accelerated aging in the irradiated brain."
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"Following these survivors many decades, or throughout life, after treatment with cranial radiotherapy and chemotherapy is highly warranted for a broader understanding of long-term outcome in this patient group."
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C.Follin, et al
Impaired brain metabolism and neurocognitive function in childhood leukemia survivors despite complete hormone supplementation in adulthood
Psychoneuroendocrinology -- Volume 73 -- November 2016 -- page 157
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TheETG cancer repair —– http://theetgtrackclub.com/documents/TheETGcancerkill.pdf

 

“The aim of this meta-analysis of cohort studies was to investigate the association between food intake and dietary patterns and overall mortality among cancer survivors.”
“A total of 117 studies enrolling 209,597 cancer survivors were included.”

“Higher intakes of vegetables and fish were inversely associated with overall mortality, and higher alcohol consumption was positively associated with overall mortality….”

“Adherence to the highest category of diet quality was inversely associated with overall mortality, as was adherence to the highest category of a prudent/healthy dietary pattern. The Western dietary pattern was associated with increased risk of overall mortality.”

“Adherence to a high-quality diet and a prudent/healthy dietary pattern is inversely associated with overall mortality among cancer survivors, whereas a Western dietary pattern is positively associated with overall mortality in this population.”

C.Schwedhelm
Effect of diet on mortality and cancer recurrence among cancer survivors: a systematic review and meta-analysis of cohort studies
Nutrition Reviews — 74 #12 — December 2016 — page 737

type 2 diabetes -vs- short duration high intensity training……

“This study investigated effects of high-intensity aerobic interval training on….Hemoglobin type A1C, insulin resistance….blood pressure, and blood lipid profile among persons with Type 2 diabetes.”

“38 individuals with Type 2 diabetes completed 12 weeks of supervised training. high-intensity aerobic interval training consisted of 4 × 4 minutes of walking or running uphill at 85–95% of maximal heart rate….”

“…..a reduction in HbA1c by −0.58% points (from 7.78 to 7.20%) was found in high-intensity aerobic interval training.”

“These improvements were significant different from Moderate intensity training.”

“High-intensity aerobic interval training is an effective exercise strategy to improve aerobic fitness and reduce risk factors associated with Type 2 diabetes.

E.M.Støa, et al
High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes
European Journal of Applied Physiology — Volume 117 #3 — March 2017 — page 455

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“We tested the hypothesis that low-volume high-intensity swimming has a larger impact on insulin sensitivity and glucose control than high-volume low-intensity swimming in inactive premenopausal women with mild hypertension.”
“62 untrained premenopausal women…..”

“15-week intervention period, high-intensity performed 3 weekly 6 – 10 × 30-seconds all-out swimming intervals interspersed by 2-minute recovery periods…..”
“….low-intensity swam continuously for 1 hour at low intensity…”

“These findings suggest that low-volume high-intensity intermittent swimming is an effective and time-efficient training strategy for improving insulin sensitivity, glucose control and biomarkers of vascular function in inactive, middle-aged mildly hypertensive women.”

L.J.Connolly, et al
Low-volume high-intensity swim training is superior to high-volume low-intensity training in relation to insulin sensitivity and glucose control in inactive middle-aged women
European Journal of Applied Physiology — Volume 116 #10 — October 2016 — page 1889

“The aim of this study was to assess the relationship between vitamin D and physical performance in physically active children.”
“In conclusion, a low plasma 25-OHD level was associated with decreased muscle strength, agility, and jumping and sprinting abilities in physically active children.”

“Vitamin D inadequacy may limit exercise performance.”.

I.Bezrati, et al
Association of plasma 25-hydroxyvitamin D with physical performance in physically active children
Canadian Journal Of Applied Physiology — Volume 41 #11 — November 2016 — page 1124

“Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability.”
“We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents.”

“We included information from 12 countries participating in the Prospective Urban Rural Epidemiological study, a prospective cohort study of individuals aged 35–70 years.”
“We used Cox proportional hazards regression to study associations with mortality, cardiovascular disease, myocardial infarction, stroke, alcohol-related cancer, injury, admission to hospital, and for a composite of these outcomes.”
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“We included 114,970 adults…..”
“Median follow-up was 4.3 years…..”
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“Current drinking was reported by 36,030 (31%) individuals, and was associated with…….increased alcohol-related cancers, and injury.”
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“High intake was associated with increased mortality.”
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“….we identified sufficient commonalities to support global health strategies and national initiatives to reduce harmful alcohol use.”
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A.Smyth, et al
Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
Lancet — Volume 386 #10007 — November 14, 2015 — page 1945

 

TheETG Competent Self-Care Packets

alcohol & caffeine —– http://theetgtrackclub.com/documents/TheETGstopalcoholcaffeine.pdf

“Chronic alcohol consumption causes multifaceted damage to the central nervous system….”
S.Samantaray, et al
Chronic intermittent ethanol induced axon and myelin degeneration is attenuated by calpain inhibition
Brain Research — Volume 1622 — October 5, 2015 — page 7
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alcohol
— alcohol metabolism product = acetaldehyde….a pro-oxidant
— acetaldehyde inhibits DNA repair enzymes
— acetaldehyde alters cell membranes, causes inflamatory reactions
— acetaldehyde leads to increases in homocysteine
— acetaldehyde leads to glutathione depletion [the human body’s anti-oxidant defense]
— alcohol increases estradiol [estrogen] levels 300% for 4 – 5 hours [to levels above that achieved via estrogen replacement therapy]. The effects are cumulative.

alcohol & caffeine —– http://theetgtrackclub.com/do…/TheETGstopalcoholcaffeine.pdf

TheETG cancer repair —– http://theetgtrackclub.com/documents/TheETGcancerkill.pdf

TheETG heart disease repair —– http://theetgtrackclub.com/documents/TheETGheartfix.pdf

Nutrition Medicine = food and/or supplements as medicine
fish oil in mothers -vs- asthma in babies…..
“Reduced intake of n−3 long-chain polyunsaturated fatty acids may be a contributing factor to the increasing prevalence of wheezing disorders. We assessed the effect of supplementation with n−3 long-chain polyunsaturated fatty acids in pregnant women on the risk of persistent wheeze and asthma in their offspring.”
“We randomly assigned 736 pregnant women at 24 weeks of gestation to receive 2.4g of n−3 long-chain polyunsaturated fatty acids (fish oil) or placebo (olive oil) per day.”
.
“A total of 695 children were included in the trial, and 95.5% completed the 3-year, double-blind follow-up period.”
.
“The risk of persistent wheeze or asthma in the treatment group was 16.9%, versus 23.7% in the control group, corresponding to a relative reduction of 30.7%.”
.
“…..supplementation with n−3 long-chain polyunsaturated fatty acids was associated with a reduced risk of infections of the lower respiratory tract….”
.
“Supplementation with n−3 long-chain polyunsaturated fatty acids in the third trimester of pregnancy reduced the absolute risk of persistent wheeze or asthma and infections of the lower respiratory tract in offspring by approximately 7 percentage points, or one third.”
.
H.Bisgaard, et al
Fish Oil–Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring
New England Journal Of Medicine — Volume 375 #26 — December 29, 2016 — page 2530

“Spinal cord injury is a traumatic event from which there is limited recovery of function, despite the best efforts of many investigators to devise realistic therapeutic treatments. Partly this is due to the multifaceted nature of spinal cord injury, where there is considerable disarray and dysfunction secondary to the initial injury.”

“Here we focus on a single strategy, exercise/physical training, which appears to have multiple applications and benefits for an acute or chronic Spinal cord injury.”
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“Exercise has been demonstrated to be advantageous at cellular and biochemical levels, as well as being of benefit for the whole animal or human subject.”
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Data from our lab and others will be discussed to further elucidate the many positive aspects of implementing exercise following injury and to suggest that rehabilitation is not the sole target of a training regimen following Spinal cord injury.”
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H.R. Sandrow-Feinberg, J.D. Houle
Exercise after spinal cord injury as an agent for neuroprotection, regeneration and rehabilitation
Brain Research — Volume 1619 — September 4, 2015 — page 12

quadriplegic, paraplegic nerve repair training —– http://theetgtrackclub.com/documents/TheETGnervequadpara.pdf

 

 

type 2 diabetes -vs- short duration high intensity training……

“This study investigated effects of high-intensity aerobic interval training on….Hemoglobin type A1C, insulin resistance….blood pressure, and blood lipid profile among persons with Type 2 diabetes.”

“38 individuals with Type 2 diabetes completed 12 weeks of supervised training. high-intensity aerobic interval training consisted of 4 × 4 minutes of walking or running uphill at 85–95% of maximal heart rate….”
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“…..a reduction in HbA1c by −0.58% points (from 7.78 to 7.20%) was found in high-intensity aerobic interval training.”
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“These improvements were significant different from Moderate intensity training.”
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“High-intensity aerobic interval training is an effective exercise strategy to improve aerobic fitness and reduce risk factors associated with Type 2 diabetes.
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E.M.Støa, et al
High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes
European Journal of Applied Physiology — Volume 117 #3 — March 2017 — page 455

Cancer causation basics

You’ve worked a job/career for 2 to 4 decades where the nature of the beast is that you’ve had your non-masked nose and mouth inside low ventilation rooms of the houses you’ve been painting. Worked in a science lab or hospital with your non-gloved hands dipping into fluids containing formaldehyde or other DNA strand breaking oxidants. Worked in office buildings and houses laying carpets that off-gas into your non-masked nose and mouth. You’ve worked 2 to 4 decades in any job/career in America from a suit & tie office to a coal mine that exposes you to DNA strand breaking stuff.

Added to this load there’s the stuff you drink/eat/do every weekend or everyday since you were a teenager [alcohol, caffeine, cigarettes].

2 to 4 decades of stuff going into your blood stream and onward to various tissues comprising various organs, eventually to a location that happens to be your weakest link. Eventually the volume of it all surpasses the volume of anti-oxidants you receive from your food, supplements, and exercise [a.k.a. “you eat right and exercise”]. Line of defense #1 of 3 lowered against cancer cell production and growth in whatever tissue/organ happens to be your weakest link.

The oxidants become able to initiate the rate and magnitude of DNA strand breaks necessary to become a problem. Eventually some of those DNA strand breaks are on genes that code for one or more tumor suppressors. Now you have a major problem. Line of defense #2 of 3 lowered against cancer cell production and growth in whatever tissue/organ happens to be your weakest link.

Add in the American norm of living immune system suppressing stress as a lifestyle, the over-consumption of immune system suppressing foods and substances [sugar, alcohol, etc], or simply the standard day to day house/car, bills, kids, job, dysfunctional family-coworkers-boss-marriage, test taking and term paper deadline types of stressors that perhaps the unaddressed experiences in your childhood and teenage years cause you to approach with more dysfunction than other folks do. Over time these collectively lower long term immune system functioning. Line of defense #3 of 3 lowered against cancer cell production and growth in whatever tissue/organ happens to be your weakest link.

At that point the status of things enters into the basic math equation.
The rate of cancer cell production exceeds the rate of cancer cell destruction.
Here you officially begin the lengthy journey down the path towards the day of diagnosis in your doctor’s office.

After the day of diagnosis you pursue the standard traditional treatment approach, then get branded as being “cancer free”.

You’re -not- told that there may be cancerous stem cells that went somewhat untouched by the chosen standard traditional treatment approach. Told nothing about how line of defense number 1, 2, or 3 were compromised thus you’re -not- empowered to take action accordingly. You go back to your life, business as usual. Nothing caused your cancer. Stuff happens. Nothing to see here, move along.

From here the cancer patient population self-separates into 2 groups.
Those that wanna know stuff and those that don’t.

You live in a country where seeking what caused your cancer is -not- viewed as applied knowledge acquisition and subsequent self-empowerment. It is instead viewed as a highly aversive blame game where the words “its your fault” and the phrase “don’t blame the victim” are the weapon of choice.

The medical community lives by “treat and release”. Teach nothing.

The fundraising community engages in the emotionalization of disease. Teach nothing.

Psychological norms teach you to “fight cancer” by learning nothing and doing nothing other than showing up for your scheduled appointments, endure the aversive “side effects” of standard traditional treatment approach, or start a non-profit organization number 5,529 to fund people’s careers in never ending research.

Resist the norm. The norm is -not- normal.

Know stuff. To “get cancer”, the following —has to— happen very early on in the process that follows initial damage to DNA that precedes cancer cell growth and spread……….

1 — Cell must lose ability to repair damaged DNA

2 — cell must lose ability to commit suicide once damaged DNA is detected

3 — normal functioning immune system must lose ability to kill cancer cells at a rate that exceeds cancer cell production

4 — this situation must persist for years or decades

“The phenomenon of Lumbar Disc Herniation reabsorption is well recognized. Because its overall incidence is now 66.66% according to our results, conservative treatment may become the first choice of treatment…..”
“…..overall incidence of spontaneous resorption….66.66%….”
“The incidence in the United Kingdom was 82.94%…”
“The incidence in Japan was 62.58%”
 
M. Zhong, et at
Incidence of Spontaneous Resorption of Lumbar Disc Herniation: A Meta-Analysis.
Pain Physician — Volume 20 #1 — Jan-Feb 2017 — page E45-E52

“The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. These microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut–brain axis)…..”
“This microbe–host communication is essential to maintain vital functions…..”
“….the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders.”
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B.O.Schroeder, F.Backhed
Signals from the gut microbiota to distant organs in physiology and disease
Nature Medicine — Volume 22 #10, October 2016 — page 1079

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“The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influences many aspects of host physiology, including nutrient metabolism, resistance to infection and immune system development.”
“….critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions.”
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Intestinal microbes modulate the maturation and function of tissue-resident immune cells in the central nervous system. Microbes also influence the activation of peripheral immune cells, which regulate responses to neuroinflammation, brain injury, autoimmunity and neurogenesis.”
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Accordingly, both the gut microbiota and immune system are implicated in the etiopathogenesis or manifestation of neurodevelopmental, psychiatric and neurodegenerative diseases, such as autism spectrum disorder, depression and Alzheimer’s disease.”
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T.C.Fung, et al
Interactions between the microbiota, immune and nervous systems in health and disease
Nature Neuroscience — Volume 20 #2 February 2017 — page 145

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Dr Ohhira’s = 900 million CFU [number of bacteria in a capsule]
—– TH-10 in Dr Ohhira’s supposedly stronger than all other bacteria
 
Reg’Activ = 4 to 6 billion CFU of ME-3 [number of bacteria in a capsule]
—– ME-3 in Reg’Activ supposedly produces glutathione
 
animated video of probiotics
 
Dr Ohhira’s
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Reg’Activ

 

The combo of vitamin C and Vitamin K3 being used to kill cancer cells in breast cancer, prostate cancer, bladder cancer, etc, etc,. Human clinical trials have been underway in several areas.
The study below is about bladder cancer.

Journal of Cancer Science & Therapy [2013, 5:325-333]……
Vitamin C and Vitamin K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells
James M. Jamison, Ph.D
St. Thomas Hospital
444 N. Main Street, Akron, Ohio 44310, US

“……Henryk Taper and coworkers for the treatment of liver and other cancers by using a combination of vitamin C and vitamin K3 (VC:VK3) in a 100:1 ratio. Taper showed that vitamin C reactivated DNase II, while vitamin K3 reactivated DNase I with the combination synergistically causing tumor cell death.”
“These results have been extended into the clinical setting with a phase I/IIa clinical trial for end stage prostate cancer which demonstrated both safety and efficacy.”

“Vitamin C, Vitamin K3 and the combination were evaluated against human bladder cancer cell lines RT-4 and T24 to evaluate their synergistic anticancer activity.”

“….combination Vitamin C and vitamin K3 was able to cause autoschizic cell death through oxidative stress, thiol depletion, lipid peroxidation, modification of ATP levels and calcium regulation.”

“Because of these results, combination Vitamin C and vitamin K3 was granted orphan drug status for the treatment of metastatic or locally advanced, inoperable transitional cell carcinoma of the urothelium (stage III and IV bladder cancer).”
“Efforts are underway to conduct a phase II clinical trial for this indication.”

antibiotics and brain dysfunction……
“Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health.”
“16S rDNA sequencing confirmed antibiotic-induced microbial community disruption, and metabolomics revealed that gut dysbiosis was associated with depletion of bacteria-derived metabolites in the colon and alterations of lipid species and converted microbe-derived molecules in the plasma.”
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“Importantly, novel object recognition, but not spatial, memory was impaired in antibiotic-treated mice.”
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” This cognitive deficit was associated with brain region-specific changes in the expression of cognition-relevant signaling molecules, notably brain-derived neurotrophic factor, N-methyl-d-aspartate receptor subunit 2B, serotonin transporter and neuropeptide Y system.”
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“We conclude that circulating metabolites and the cerebral neuropeptide Y system play an important role in the cognitive impairment and dysregulation of cerebral signaling molecules due to antibiotic-induced gut dysbiosis.”
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E.E. Fröhlich, et al
Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
Brain, Behavior, and Immunity — Volume 56 — August 2016 — page 140

Nutrition Medicine = food and/or supplements as medicine.
I first heard Dean speak back in the 1990’s here in Austin at a medical conference presenting research on alternative medicine…..the days when the prevailing “wisdom” in the American medical community was that heart disease was a terminal diagnosis. He presented the data that he published in the Journal Of The American Medicine Association showing non-prescription drug reversal of clogged blood vessels via change in the type of food consumed.
The medical community labeled him a quack.

Certain folks in the drugs only, drugs always, drugs forever medical community continue to do so today.
Sprinting down the wrong path and shouting down those on the right path is what happens in medicine, in science, in sport, in life when you put dogma ahead of data.
Hence my mantra, put data ahead of dogma. Follow the data, not the crowd.

Today his reversing heart disease treatment program is funded by Medicare in spite of the stone throwing by folks that practice medicine in glass houses. President Obama appointed Dr Dean Ornish to the Presidential White House Advisory Group on Prevention, Health Promotion, and Integrative and Public Health.

Dr. Dean Ornish TEDx Talk — https://www.youtube.com/watch?v=QYmInK5xo6g&app=desktop

Nutrition medicine = food and/or supplements as medicine
resveratrol -vs- type-2 diabetes
“The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression……in subjects with Type 2 diabetes mellitus.”
“…studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1 activity. Sub- sequent upregulation of AMPK and GLUT4 expression are associated with improved insulin sensitivity in peripheral tissues.”

“10 subjects….randomized in a double-blind….”

“3g resveratrol or placebo daily for 12 weeks”

“There was a significant increase in both SIRT1 expression and p-AMPK to AMPK expression ratio in the resveratrol group compared with the placebo group.”

“In patients with type-2 diabetes, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. These findings indicate that resveratrol may have beneficial exercise-mimetic effects in patients with type-2 diabetes.”

K.P. Goh, et al
Effects of Resveratrol in Patients With Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
International Journal of Sport Nutrition and Exercise Metabolism — Volume 24 #1, February 2014 — page 2

Lotta studies show that fish oil improves ADHD in kids.
This is one of the many studies on what happens to kids after birth as a result of giving an essential fat to pregnant mothers.
“Docosahexanoic acid (DHA) is an important constituent of the brain.”
“We evaluated global cognition, behavior, and attention at age 5 years…….in a randomized controlled trial of prenatal DHA supplementation.”

“A total of 1094 women were randomly assigned to receive 400mg of either DHA or placebo/day from 18 to 22 weeks of pregnancy until delivery. We assessed cognitive development and behavioral and executive functioning, including attention, in 797 offspring at age 5 years….”

“Prenatal exposure to DHA may contribute to improved sustained attention in preschool children.”

Usha Ramakrishnan, et al
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
American Journal Of Clinical Nutrition — Volume 104 #4 — October 2016 — page 1075

Comparative effectiveness research, osteo-arthritis in knees.
platelet-rich plasma -vs- corticosteroid injection…….
“Evidence on the effect of platelet-rich plasma in treating osteoarthritis is insufficient. Therefore, the present study compares the effects of a one-time injection of platelet-rich plasma and corticosteroid”.
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“In the present randomized double blind clinical trial, the participants who suffered from knee osteoarthritis (Grades II/III), were randomly divided into two groups: intra articular injection of platelet-rich plasma and corticosteroid.”
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“….assessed before, 2-months, and 6-months after interventions.”
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“41 participants (48 knees) were involved in the research (66.7% women; average age of 61.1±7.0 years old). Compared to the group treated with corticosteroid, pain relief, symptom free, activities of daily living and quality of life in the platelet-rich plasma group were significantly higher….”
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“Platelet-rich plasma was significantly more helpful for relieving patients’ pain compared to corticosteroids.”
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“Our study demonstrated that one shot of platelet-rich plasma injection, decreased joint pain more and longer-term, alleviated the symptoms, and enhanced the activity of daily living and quality of life in short-term duration in comparison with corticosteroid.”
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B. Forogh, et al
Effect of single injection of platelet-rich plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial
The Journal of Sports Medicine and Physical Fitness — Volume 56 #7&8 — July-August 2016 — page 901

Nutrition Medicine….food and/or supplements as medicine.
terms……DHA = one of the fats in fish oil…..cortisol = stress hormone
“To test the effectiveness of prenatal docosahexaenoic acid (DHA) supplementation on birth outcomes and infant development in a sample of African American women with Medicaid insurance……”
“The Nutrition and Pregnancy Study is a double-blind, randomized controlled trial of prenatal DHA supplementation conducted between 2012 and 2014.”
“Participants were recruited from obstetric clinics at the University of Pittsburgh Medical Center.”

“64 pregnant, African American women were enrolled at 16–21 weeks of gestation and randomized to either 450 mg/day of DHA or a soybean placebo.”
“….complete data were obtained for 49 infants at the 3-month assessment.”

“Infants of mothers who received DHA supplementation had higher birth weight than infants of mothers receiving placebo….”

“Infants of mothers who received DHA compared with infants of mothers receiving placebo had lower levels of cortisol in response……”

“Infants of women living in urban, low-income environments who received DHA supplementation had more optimal birth outcomes and more modulated cortisol response to a stressor. DHA supplementation may be effective in attenuating the negative effects of prenatal stress on offspring development.”

K.Keenan, et al
The effect of prenatal docosahexaenoic acid supplementation on infant outcomes in African American women living in low-income environments: A randomized, controlled trial
Psychoneuroendocrinology — Volume 71 — September 2016 — page 170

The war on sugar.
Just like the last decade’s war on fat and the 1990’s war on cholesterol there are a large number of friendly fire and collateral damage incidents taking place.
If you’re in your 40’s or older, the cholesterol that your bottle of lipitor or crestor or pravastain is preventing your brain from getting is one day gonna be quite regrettable for you, your family, and whoever has to be your caretaker.

Not a good idea to look at the fat in the cod you just reeled in during your fishing trip to Alaska the same way you look at the fat of the bacon in your pan that came from an animal that lived most of its life in a small cage and fed whatever.

And in the war on sugar, understand that the sugar in organic Aloe juice isn’t the sugar in Kool Aid. There are sugars that suppress immune cell function and there are sugars that enhance it. There are sugars essential to life and there are sugars that are accelerating your rate of aging.

In the war on cholesterol, fat, red meat, and sugar be careful.
There are many fire and brimstone nutrition preachers not carefully railing against whatever the latest thing to rail against happens to be. The outcome for many well meaning listeners is that essential nutrients for long term health become the victims of friendly fire and end up as collateral damage.

cholesterol………..there do exist essential functions in the body
Fat……………………there do exist essential fatty acids
protein………………there do exist essential amino acids
carbohydrate…….there do exist essential sugars

Don’t throw the baby out with the bath water.

[FDA, Friday September 2, 2016]
“Companies will no longer be able to market antibacterial washes with these ingredients because manufacturers did not demonstrate that the ingredients are both safe for long-term daily use and more effective than plain soap and water in preventing illness and the spread of certain infections.”

“This final rule applies to consumer antiseptic wash products containing one or more of 19 specific active ingredients, including the most commonly used ingredients – triclosan and triclocarban.”
“Consumers may think antibacterial washes are more effective at preventing the spread of germs, but we have no scientific evidence that they are any better than plain soap and water,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research. “In fact, some data suggests that antibacterial ingredients may do more harm than good over the long-term.”


[FDA, December 24, 2013]
“……antibacterial soap products contain chemical ingredients, such as triclosan and triclocarban, which may carry unnecessary risks given that their benefits are unproven.”

“New data suggest that the risks associated with long-term, daily use of antibacterial soaps may outweigh the benefits,” Rogers says. There are indications that certain ingredients in these soaps may contribute to bacterial resistance to antibiotics, and may have unanticipated hormonal effects that are of concern to FDA.”

———————————————————————-

“In April, the WHO declared that the problem “threatens the achievements of modern medicine. A post-antibiotic era — in which common infections and minor injuries can kill — is a very real possibility for the 21st century.”
“……a report on antibiotic resistance linked to an executive order from President Barack Obama, who directed the National Security Council to work with a governmental task force and a nongovernmental advisory council to develop a national action plan by February 2015.”
“…..antibiotics in a market that is currently worth more than $40 billion annually for drugs that are starting to fail.

C.Nathan, M.D., et al
Resistance — Problems, Progress, and Prospects
New England Journal Of Medicine…..volume 371 #19…..November 6, 2014….page 1761 – 1763

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[CNBC, December 11, 2014…..Drug resistance deadlier than cancer by 2050……by Catherine Boyle]
“Infections resistant to medicines will kill more people per year than cancer by 2050, and cost the world $100 trillion annually, according to a U.K. government-backed report led by Jim O’Neill, the well-known former Goldman Sachs economist.”
“The wide-ranging study, called the Review on Antimicrobial Resistance, was commissioned by the U.K. government earlier this year amid growing concerns about drug-resistant “superbugs”, including new strains of E. coli, malaria and tuberculosis.”.
“Its forecasts, based on research by RAND Europe and KPMG, suggest that drug resistance, which is estimated to have caused around 700,000 deaths globally this year, will cause 10 million by 2050 if further action is not taken.”

“The molecular mechanisms behind the obesity-breast cancer association may be regulated via adipokine secretion by white adipose tissue. Specifically, adiponectin and leptin are altered with adiposity and exert antagonistic effects on cancer cell proliferation.”
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“We set out to determine whether altering adiposity in vivo via high fat diet feeding changed the tumor growth supporting nature of adipose tissue and whether voluntary physical activity could ameliorate these high fat diet-dependent effects.”
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“We show that conditioned media created from the adipose tissue of high fat diet fed animals caused an increase in the proliferation of MCF7 cells compared with cells exposed to conditioned media prepared from the adipose of lean chow diet fed counterparts.”

“This increased proliferation was driven within the MCF7 cells by an high fat diet-dependent antagonism between AMP-activated protein kinase and protein kinase B signaling pathways, decreasing p27 protein levels via reduced phosphorylation at T198 and downregulation of adiponectin receptor 1.”
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“Physical activity can ameliorate these proliferative effects of high fat diet-conditioned media on MCF7 cells, increasing p27T198 by AMPK, reducing pAktT308, and increasing AdipoR1, resulting in cell cycle withdrawal in a manner that depends on the physical activity intensity. High physical activity (>3 km/day) completely abolished the effects of high fat diet feeding.”

“In addition, AdipoR1 overexpression mimics the effects of exercise, abolishing the proliferative effects of the high fat diet-conditioned media on MCF7 cells and further enhancing the antiproliferative effects of physical activity on the high fat diet-conditioned media.”
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“Thus voluntary physical activity represents a means to counteract the proliferative effects of adipose tissue on breast cancers in obese patients.”
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C.F. Theriau, et al
Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
Journal of Applied Physiology — Volume 121 #1 — July 2016 — page 139

“There is increasing research evidence about the causal role of alcohol in cancer, accompanied by unclear and conflicting messages in the media.”

“…the epidemiological evidence can support the judgement that alcohol causes cancer of the oropharynx, larynx, oesophagus, liver, colon, rectum and breast.”

“…..epidemiological studies also commonly report protection from cardiovascular disease associated with drinking but a high level of scepticism regarding these findings is now warranted.”

“There is strong evidence that alcohol causes cancer at seven sites in the body and probably others.”

J. Connor

Alcohol consumption as a cause of cancer

Addiction — July 21, 2016

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see several studies on alcohol and cancer located on page 62 & 63 of TheETG Competent Self-Care packet titled…..”TheETG cancer repair”

  http://theetgtrackclub.com/documents/TheETGcancerkill.pdf

The info below, yet another reason I encourage folks to see TheETG packet on reversing cavities….http://theetgtrackclub.com/documents/TheETGteethappliedresearch.pdf

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ABCNews, August 2, 2016—Feds: No evidence flossing fights gum disease

“….there’s little proof that flossing works.”

“….Associated Press asked the departments of Health and Human Services and Agriculture for their evidence, and followed up with written requests under the Freedom of Information Act. When the federal government issued its latest dietary guidelines this year, the flossing recommendation had been removed, without notice. In a letter to the AP, the government acknowledged the effectiveness of flossing had never been researched, as required.”

“One study review in 2011 did credit floss with a slight reduction in gum inflammation – which can sometimes develop over time into full-fledged gum disease. However, the reviewers ranked the evidence as “very unreliable.”

“The two leading professional groups – the American Dental Association and the American Academy of Periodontology, for specialists in gum disease and implants – cited other studies as proof of their claims that flossing prevents buildup of gunk known as plaque, early gum inflammation called gingivitis, and tooth decay. However, most of these studies used outdated methods or tested few people. Some lasted only two weeks, far too brief for a cavity or dental disease to develop. One tested 25 people after only a single use of floss.”

“Even companies with a big market share of the flossing business – by next year, the global market is predicted to reach almost $2 billion, with half in the United States, according to publisher MarketSizeInfo.com – struggled to provide convincing evidence of their claims that floss reduces plaque or gingivitis. Yet the industry has paid for most studies and sometimes designed and conducted the research.”

Babies, probiotics, and the immune system.......

“…….prenatal environment and delivery mode can shape the newborn microbiome at birth.”
“……postnatal factors, such as antibiotic treatment, diet or environmental exposure, further modulate the development of the infant’s microbiome and immune system, and exposure to a variety of microbial organisms during early life has long been hypothesized to exert a protective effect in the newborn.”

“……epidemiological studies have shown that factors that alter bacterial communities in infants during childhood increase the risk for several diseases, highlighting the importance of understanding early-life microbiome composition.”

“In this review, we describe how prenatal and postnatal factors shape the development of both the microbiome and the immune system.”
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S. Tamburini, et al
The microbiome in early life: implications for health outcomes
Nature Medicine — Volume 22 #7 — July 2016 — page 713


Mind-body medicine

Stress and skin wound healing…..

“Higher psychological stress is associated with slower dermal wound healing….”

“….immunological mechanisms behind this effect…..”

“…investigate whether immune cells present in the skin prior to wounding can affect subsequent healing in high-stress and low-stress participants.”

“…..healthy older adults and showed that higher stress was associated with significantly fewer macrophages in the skin.”

“…..younger adults and showed that higher stress was associated with significantly lower activation of immune cells in the skin.”

“lower activation of immune cells (as measured by human leukocyte antigen (HLA expression)) and fewer Langerhans cells were associated with slower healing. Together these studies show the first preliminary evidence that the number and activation of immune cells in the skin prior to wounding are affected by stress and can impact healing. Larger studies are needed to confirm these effects.”

H.Koschwanez, et al

Stress-related changes to immune cells in the skin prior to wounding may impair subsequent healing

Brain, Behavior, and Immunity….Volume 50….November 2015….page 47

Cancer 101…….

70 – 90% of all diagnosed cancers in the US are –not– an “its genetic” situation.

To “get cancer”, the following —has to— happen very early on in the process that follows initial damage to DNA that precedes cancer cell growth and spread……
1 — Cell must lose ability to repair damaged DNA
2 — cell must lose ability to commit suicide once damaged DNA is detected
3 — normal functioning immune system must lose ability to kill cancer cells at a rate that exceeds cancer cell production
4 — this situation must persist for years or decades

The point of posting this information is that in the context of prevention and cure……
1 — one can prevent the loss of and/or restore a cell’s ability to repair damaged DNA
2 — one can prevent the loss of and/or restore a cell’s ability to commit suicide
3 — one can prevent the loss of and/or restore the immune systems ability to kill cancer cells at a rate that exceeds cancer cell production
4 — one can prevent the loss of and/or restore this situation to persist for years or decades

Most importantly, if you get cancer its unlikely that you’ll be told any of this or offered a treatment that takes this approach.

A math equation.
— long term rate of cancer cell destruction exceeds the rate of cancer cell production and proliferation = you live
— long term rate of cancer cell production and proliferation exceeds the rate of cancer cell destruction = you die

Worth paying attention to what happens after cancer treatment.
Note the sentence…..”good news, you’re cancer free, see ya and have a good life”.

This is how re-occurence takes place, therefore, please set aside the desire to proclaim yourself as “cancer free”.

Instead, engage in a discussion about how did these cells fail to kill themselves the way they’re supposed to. Why didn’t the immune system kill them off the way it’s supposed to. What can be done to help cellular function so that cell suicide occurs the way its supposed to.
What can be done to help the immune system prevent a “next time”.

That’s why the conversation should not end after the good news is delivered. That should mark the beginning of the conversation, not the end.

Returning to your life, business as usual without identifying and changing –something– is for all practical purposes a death wish.

Nutrition Medicine……food and/or supplements as medicine

Vitamin D3 & Ig antibodies

“Heavy training is associated with increased respiratory infection risk and antimicrobial proteins are important in defense against oral and respiratory tract infections. We examined the effect of 14 weeks of vitamin D3 supplementation (5000 IU/day) on the resting plasma cathelicidin concentration and the salivary secretion rates of secretory immunoglobulin A (SIgA), cathelicidin, lactoferrin and lysozyme in athletes during a winter training period.”

“Blood and saliva were obtained at the start of the study from 39 healthy men who were randomly allocated to vitamin D3 supplement or placebo. Blood samples were also collected at the end of the study; saliva samples were collected after 7 and 14 weeks.”

“Only in the vitamin D3 group, the saliva immunoglobulin A and cathelicidin secretion rates increased over time. A daily 5000 IU vitamin D3 supplement has a beneficial effect in up-regulating the expression of immunoglobulin A and cathelicidin in athletes during a winter training period….”

C.S. Hea, et al

The effect of 14 weeks of vitamin D3 supplementation on antimicrobial peptides and proteins in athletes

Journal of Sports Sciences…..Volume 34 #1….January 2016

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see the free pdf packets “Competent Self-Care Packets” page of this website.

see more blog entries by clicking on one of the entries….then click on “archives” or page down and click on “more entries”.

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Mind-body medicine is founded on the basic principle that the brain controls or influences the function of all cells in the body by direct connection to them via the nervous system, or via chemical interaction via release of hormones or substances called neuro-peptides.

Hence the importance of and awareness of the existence of mind-body medicine. And the importance of utilizing mind-body medicine and integrating into the practice of medicine in the United States.