“Higher vitamin D status has been suggested to have beneficial effects on the brain.”
“…..investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke.”
“We used prospective data from the UK Biobank (37–73 years old at baseline) to examine the association between 25(OH)D concentrations with neuroimaging outcomes (N = 33,523) and the risk of dementia and stroke (N = 427,690; 3414 and 5339 incident cases, respectively)”
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“…..analyses were used to test for underlying causality for neuroimaging outcomes (N = 23,901) and dementia and stroke (N = 294,514; 2399 and 3760 cases, respectively).”
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“Vitamin D deficiency was associated with an increased risk of dementia and stroke, with the strongest associations for those with 25(OH)D <25 nmol/L (compared with 50–75.9 nmol/L…..”
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“…..the threshold effect of 25(OH)D on dementia, with the risk predicted to be 54% higher for participants at 25 nmol/L compared with 50 nmol/L. 25(OH)D…..”
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“Potential impact fraction suggests 17% of dementia could be prevented by increasing 25(OH)D to 50 nmol/L.”
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“Low vitamin D status was associated with neuroimaging outcomes and the risks of dementia and stroke even after extensive covariate adjustment. MR analyses support a causal effect of vitamin D deficiency on dementia but not on stroke risk.”
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Shreeya S.Navale, et al
Vitamin D and brain health: an observational and Mendelian randomization study
American Journal Of Clinical Nutrition — Volume 116 #2 — August 2022 — page 531