“Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes.”
‘
“Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome.”
‘
“…..antibiotic use <1 year before fecal sampling was associated with the greatest reduction in species diversity, but significant associations were also observed for use 1–4 and 4–8 years earlier.”
‘
“Use of these antibiotics 4–8 years earlier was associated with altered abundance of 10–15% of the species studied……”
“Similar results were found comparing one antibiotic course 4–8 years before sampling versus none in the past 8 years.”
”
“These findings indicate that antibiotics may have long-lasting consequences for the gut microbiome.”
‘
G. Baldanzi, et al
Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
Nature Medicine — Volume 32 #4 — April 2026 — page 1351