“To investigate the effects and potential mechanisms of long-term magnesium supplementation on neuroinflammation, demyelination, and blood–brain barrier integrity….”
“The most important function of magnesium in the Central Nervous System is that it serves as a blockade to the calcium channel in the N-methyl-D-aspartate receptor and must be removed for glutamatergic excitatory signaling to occur….”
“….magnesium attenuates brain edema….”
“Blood Brain Barrier permeability is damaged in magnesium deficiency mice.”
“Magnesium also enhances the expression of tight junction proteins by activating the S1P1-RAC1 pathway to tighten the endothelial barrier.”
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C.Fu, et al
Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood–brain barrier integrity in mice with neuromyelitis optica spectrum disorder
Brain Research – Volume 1846