“Early life adversity is associated with a higher risk for diseases in adulthood.”
“Although the pathophysiological effects of Early life adversity are varied, there may be a unifying role for the immune system in all of the long-term pathologies such as chronic inflammatory disorders (autoimmune diseases, allergy, and asthma).”

“Recently, significant efforts have been made to elucidate the long-term effects Early life adversity has on immune function, as well as the mechanisms underlying these immune changes.”
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“Besides the immune system, also the stress system and health behaviors are altered in Early life adversity.”
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“We discuss probable underlying mechanisms based on epigenetic programming that could explain the Early life adversity immune phenotype and whether this is a direct effect of immune programming or an indirect consequence of changes in behavior or stress reactivity.”
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“Understanding the underlying mechanisms will help define effective strategies to prevent or counteract negative Early life adversity-associated outcomes.”
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M.M.C.Elwnspoek, et al
The effects of early life adversity on the immune system
Psychoneuroendocrinology — Volume 82 — August 2017 — page 140