“Given the moderate efficacy of the currently available antidepressants
in the treatment of major depressive disorder, the identification of
agents that are both able to enhance the effectiveness of
antidepressants and have a good safety profile is a reasonable task for
current psychopharmacology.”
“….investigations suggest that
several nutraceuticals…..may be effective and safe as adjunct
therapeutic agents to conventional antidepressants. To identify such
active ingredients we first performed a systematic literature search….”
.
“As a result of those efforts, we found more than 20 agents (e.g.
S-Adenosyl-L-Methionine; folate; ω-3 fatty acids; curcumin;
N-acetylcysteine….) that are supposedly effective in the augmentation
of standard antidepressants treatment. We discussed the possible
mechanisms of the antidepressant actions of those agents, as well as the
preclinical and clinical evidence for their efficacy as stand-alone and
adjunct treatments for major depressive disorder.”
.
P.Dome, et al
Natural health products, dietary minerals and over-the-counter
medications as add-on therapies to antidepressants in the treatment of
major depressive disorder: a review
Brain Research Bulletin — Volume 146 — March 2019 — page 51