“Given the moderate efficacy of the currently available antidepressants in the treatment of major depressive disorder, the identification of agents that are both able to enhance the effectiveness of antidepressants and have a good safety profile is a reasonable task for current psychopharmacology.”
“….investigations suggest that several nutraceuticals…..may be effective and safe as adjunct therapeutic agents to conventional antidepressants. To identify such active ingredients we first performed a systematic literature search….”
“As a result of those efforts, we found more than 20 agents (e.g. S-Adenosyl-L-Methionine; folate; ω-3 fatty acids; curcumin; N-acetylcysteine….) that are supposedly effective in the augmentation of standard antidepressants treatment. We discussed the possible mechanisms of the antidepressant actions of those agents, as well as the preclinical and clinical evidence for their efficacy as stand-alone and adjunct treatments for major depressive disorder.”
P.Dome, et al
Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a review
Brain Research Bulletin — Volume 146 — March 2019 — page 51