“Chronic fatigue syndrome is a neurological disorder characterized by persistent fatigue. Previous studies have shown structural and functional brain alterations in chronic fatigue syndrome patients.”

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“Chronic fatigue syndrome patients exhibited reduced fractional anisotropy in the left cingulum parolfactory tract and the left cingulum frontal-parahippocampal tract.”

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“…..disruptions in these two tracts were localized to the middle-posterior portion of the cingulum bundle.”

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“…..causal analysis demonstrated that recovery of these segmentally disrupted tracts was associated with improvements in fatigue symptoms.”

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“This large-sample study provides comprehensive insights into microstructural impairments induced by chronic fatigue and highlights the critical role of the cingulum bundle in the pathological mechanisms of chronic fatigue syndrome, thereby advancing our understanding of chronic fatigue syndrome.”

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K. Wu, et al

Microstructural white matter impairments in chronic fatigue syndrome: Evidence of segmental injury in the cingulum bundle

Brain, Behavior, and Immunity — Volume 234 — January 2026