“In older adults without cognitive impairment with higher levels of brain amyloid-β, physical inactivity was associated with accelerated accumulation of tau pathology and faster cognitive and functional decline.”

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“These findings suggest that even modest increases in daily physical activity might be linked to slower progression of preclinical Alzheimer’s disease.”

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W.-Y. W. Yau, et al.

Physical activity linked to slower tau protein accumulation and cognitive decline

Nature Medicine — Volume 31 #12 — December 2025 — page 3396