“A treatment for heart failure that could promote myocardial regeneration has long been sought.”
“Here we conduct the HEAL-CHF trial (n = 20; 18 male and 2 female), in which patients with advanced heart failure with reduced ejection fraction were randomized to receive intramyocardial injections of allogeneic human induced pluripotent stem cell-derived cardiomyocytes or were uninjected.”
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“…..cell transplantation provided significantly greater improvements in 6-min walk distance, global myocardial perfusion and relative wall thickening, compared with coronary artery bypass grafting alone.”
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H.Zhang, et al
Intramyocardial injection of allogeneic human induced pluripotent stem cell-derived cardiomyocytes in advanced ischemic heart failure: an early-stage randomized trial
Nature Medicine — Volume 32 #9 — September 2026 — page 3331