“A motor unit consists of a single motor neuron and the group of muscle fibers it innervates. With aging, motor neuron loss leads to a decrease in the number of motor units, resulting in the denervation of muscle fibers.”
“Denervated muscle fibers may either be lost or reinnervated by collateral sprouting from neighboring surviving motor neurons.”
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“…..older adults who have engaged in long-term high-intensity resistance training exhibit little evidence of muscle fiber grouping compared with their less active counterparts, and masters athletes have been shown to maintain motor unit numbers comparable to those of young adults. Collectively, these findings suggest that although motor unit remodeling is an age-related process, its extent varies markedly among individuals.”
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“…..the objective of this study was to determine the association between muscle strength and motor unit number, motor unit size, and indices reflecting motor unit size composition in older adults.”
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“This study used a part of previously reported research data from young, middle-aged, and older adults. Data from 49 older adults aged 60 to 82 yr old were used in this study.”
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“To address the primary objective of this study, examining the relationship between motor unit remodeling and muscle strength, correlation analyses were performed using the entire sample.”
“A significant correlation was observed between several electrophysiological parameters reflecting motor unit remodeling and pinch strength.”
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“The present study demonstrated that older adults with a greater extent of motor unit remodeling exhibited lower muscle strength.”
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“…..older adults with less advanced neuromuscular degeneration exhibit greater muscle strength. Although maintaining reinnervation capacity has been considered important for preserving muscle strength in older adults, the present findings suggest that attenuating age-related neuromuscular degeneration itself, including denervation and subsequent reinnervation, may also be important.”
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M Kuniki, et al
Association between motor unit remodeling and interindividual variability in muscle strength of older adults
Journal Of Applied Physiology — Volume 141 #4 — October 2026