“In recent years, research in this field has been focused on developing possible treatments that could stimulate hair follicle growth….”

“Particular attention has been given to the use of exosomes, which are known to act as cargoes for the transport of bioactive molecules, some of which are involved in regenerative mechanisms.”

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“Exosomes are a subset of extracellular microvesicles, with an average diameter of 30–150 nanometers, involved in intercellular communication and cellular trafficking. Exosomes are critically involved in human health, including development, immunity, and tissue homeostasis. They are produced by various human and animal cells, such as red blood cells, lymphocytes, and dendritic cells, as well as being concentrated in various biological fluids such as milk, urine, and blood plasma. More recently, exosome-like vesicles have also been isolated in plants.”

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“Exosomes are produced through the inward budding of endosomes, resulting in the formation of membrane-surrounded multivesicular bodies, which are secreted through the fusion of MVBs with the cell membrane. Once internalized, they can fuse with the membrane of endosomes, allowing the transfer of their contents into the cytoplasm of target cells.”

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“Their functional components include proteins, lipids, amino acids, and different RNA patterns.”

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“Due to their high biocompatibility, exosomes are utilized in many biomedical and therapeutic applications, from drug delivery in various types of cancer (pancreatic, liver, gastric), to the uptake of pathogenic molecules involved in the etiogenesis of neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, to tissue stimulation in the field of regenerative medicine.”

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“The purpose of the present study was to evaluate in vitro the action of some compounds on hair growth and regeneration in the dermal papilla and to compare their efficacy.”

“We have tested the effectiveness of plant-derived nanovesicles, exosomes from human umbilical cord blood stem cells, and colostrum.”

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“Exosomes and nanovesicles from these matrices have not yet been investigated regarding their possible effects on hair regeneration, whereas interesting results have been achieved with exosomes and factors present in colostrum….”

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“We compared in vitro, on cultures of human hair follicles, the effect on hair growth and regeneration of the dermal papilla of plant-derived nanovesicles, exosomes from cord blood stem cells and bovine colostrum, a mixture of growth factors and cytokines purified from bovine colostrum, called GF20, and a new compound called HAIR & SCALP COMPLEX obtained by adding exosomes isolated from colostrum to GF20.”

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“….regenerative action of a mixture of exosomes and 20 growth factors, both derived from bovine colostrum, called HAIR & SCALP COMPLEX, to counteract the loss and/or the failure to regenerate in the hair follicles that we examined.”

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“…..a mixture of growth factors and cytokines isolated from colostrum, which contains 20 different biologically active factors essential for several functions.”

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“The stimulatory effect on hair growth was evaluated through an in vitro test involving treatment for 18 days. At the end of the exposure, GF20 and HSC50+ resulted not only in an extension of follicle growth compared to all other compounds tested, but also in an increase in the number of dermal papilla cells.”

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“Our study has allowed us to identify a natural product with high potential in the treatment of hair regeneration.”

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“Based on the results obtained, nanovesicles from plants and exosomes from stem cells had no significant effect on the stimulation of hair growth, unlike exosomes from colostrum.”

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Greta Ferruggia, et al

Effectiveness of a Novel Compound HAIR & SCALP COMPLEX on Hair Follicle Regeneration

Cosmetics — Volume 11 #2 — February 2024